Title : PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

Pub. Date : 2004 May

PMID : 15107844






1 Functional Relationships(s)
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1 Hepatic PGC-1 expression is elevated in mouse models of this disease, where it promotes constitutive activation of gluconeogenesis and fatty acid oxidation through its association with the nuclear hormone receptors HNF-4 and PPAR-alpha, respectively. Fatty Acids peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus