Title : Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle.

Pub. Date : 2006 Feb

PMID : 16223979






3 Functional Relationships(s)
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1 Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle. Triglycerides peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
2 In conclusion, from studies in these two animal models, it appears that PGC-1alpha protein expression is inversely related to components of intramuscular lipid metabolism, because 1) PGC-1alpha protein expression is downregulated when triacylglycerol synthesis rates, an index of intramuscular lipid metabolism, are increased, and 2) PGC-1alpha protein expression is upregulated when triacylglycerol synthesis rates are reduced. Triglycerides peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
3 In conclusion, from studies in these two animal models, it appears that PGC-1alpha protein expression is inversely related to components of intramuscular lipid metabolism, because 1) PGC-1alpha protein expression is downregulated when triacylglycerol synthesis rates, an index of intramuscular lipid metabolism, are increased, and 2) PGC-1alpha protein expression is upregulated when triacylglycerol synthesis rates are reduced. Triglycerides peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus