Pub. Date : 2006 Feb 3
PMID : 16364253
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. | Fatty Acids | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |
| 2 | Here we show that AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) increases mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR-stimulated increase in fatty acid oxidation. | acadesine | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |
| 3 | These data suggest that a novel transcriptional regulatory mechanism involving PPARalpha and PGC-1 exists that is responsible for long-term stimulation of fatty acid oxidation in skeletal muscle by AICAR. | Fatty Acids | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |