| Protein Name | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
|---|---|
| Organism | Mus musculus |
| Gene ID | 19017 |
| Gene Symbol | Ppargc1a |
| UniProt | O70343 (PRGC1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
619
Total Number of Articles : 1017 |
Description |
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
| Gene Summary |
This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
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