Title : Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.

Pub. Date : 2007 Feb 20

PMID : 17261654






1 Functional Relationships(s)
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1 CONCLUSIONS: These results demonstrate that mitochondrial biogenesis occurs early in the development of diabetic cardiac dysfunction through a transcriptional regulatory circuit that involves activation of PGC-1alpha gene expression by the fatty acid-activated nuclear receptor PPARalpha. Fatty Acids peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus