Pub. Date : 2004 Apr
PMID : 15024092
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | By phosphorylating activating transcription factor 2 (ATF-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a PPAR response element that both reside within a critical enhancer motif of the UCP1 gene. | Cyclic AMP | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |
2 | Activation of ATF-2 by p38 MAPK additionally serves as the cAMP sensor that increases expression of the PGC-1alpha gene itself in brown adipose tissue. | Cyclic AMP | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | Mus musculus |