Title : p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.

Pub. Date : 2004 Apr

PMID : 15024092






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 By phosphorylating activating transcription factor 2 (ATF-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a PPAR response element that both reside within a critical enhancer motif of the UCP1 gene. Cyclic AMP peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
2 Activation of ATF-2 by p38 MAPK additionally serves as the cAMP sensor that increases expression of the PGC-1alpha gene itself in brown adipose tissue. Cyclic AMP peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus