Pub. Date : 2021 Dec
PMID : 33734011
16 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Trelagliptin stimulates osteoblastic differentiation by increasing runt-related transcription factor 2 (RUNX2): a therapeutic implication in osteoporosis. | trelagliptin | RUNX family transcription factor 2 | Homo sapiens |
| 2 | Trelagliptin stimulates osteoblastic differentiation by increasing runt-related transcription factor 2 (RUNX2): a therapeutic implication in osteoporosis. | trelagliptin | RUNX family transcription factor 2 | Homo sapiens |
| 3 | Trelagliptin is a long-acting inhibitor of DPP-4 used for the management of type 2 diabetes mellitus. | trelagliptin | dipeptidyl peptidase 4 | Homo sapiens |
| 4 | Firstly, Trelagliptin increased the activity of alkaline phosphatase (ALP) and promoted osteoblastic calcium deposition. | trelagliptin | alkaline phosphatase, placental | Homo sapiens |
| 5 | Firstly, Trelagliptin increased the activity of alkaline phosphatase (ALP) and promoted osteoblastic calcium deposition. | trelagliptin | alkaline phosphatase, placental | Homo sapiens |
| 6 | Additionally, treatment with Trelagliptin upregulated ALP, osteocalcin (OCN), osteopontin (OPN), and bone morphogenetic protein-2 (BMP-2). | trelagliptin | alkaline phosphatase, placental | Homo sapiens |
| 7 | Additionally, treatment with Trelagliptin upregulated ALP, osteocalcin (OCN), osteopontin (OPN), and bone morphogenetic protein-2 (BMP-2). | trelagliptin | bone gamma-carboxyglutamate protein | Homo sapiens |
| 8 | Additionally, treatment with Trelagliptin upregulated ALP, osteocalcin (OCN), osteopontin (OPN), and bone morphogenetic protein-2 (BMP-2). | trelagliptin | bone gamma-carboxyglutamate protein | Homo sapiens |
| 9 | Additionally, treatment with Trelagliptin upregulated ALP, osteocalcin (OCN), osteopontin (OPN), and bone morphogenetic protein-2 (BMP-2). | trelagliptin | secreted phosphoprotein 1 | Homo sapiens |
| 10 | Additionally, treatment with Trelagliptin upregulated ALP, osteocalcin (OCN), osteopontin (OPN), and bone morphogenetic protein-2 (BMP-2). | trelagliptin | secreted phosphoprotein 1 | Homo sapiens |
| 11 | Additionally, treatment with Trelagliptin upregulated ALP, osteocalcin (OCN), osteopontin (OPN), and bone morphogenetic protein-2 (BMP-2). | trelagliptin | bone morphogenetic protein 2 | Homo sapiens |
| 12 | Additionally, treatment with Trelagliptin upregulated ALP, osteocalcin (OCN), osteopontin (OPN), and bone morphogenetic protein-2 (BMP-2). | trelagliptin | bone morphogenetic protein 2 | Homo sapiens |
| 13 | Notably, Trelagliptin increased RUNX2, a major regulator of osteoblastic differentiation. | trelagliptin | RUNX family transcription factor 2 | Homo sapiens |
| 14 | Blockage of AMPK with compound C abolished the effects of Trelagliptin in RUNX2 and osteoblastic differentiation, suggesting the involvement of AMPK. | trelagliptin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 15 | Blockage of AMPK with compound C abolished the effects of Trelagliptin in RUNX2 and osteoblastic differentiation, suggesting the involvement of AMPK. | trelagliptin | RUNX family transcription factor 2 | Homo sapiens |
| 16 | Blockage of AMPK with compound C abolished the effects of Trelagliptin in RUNX2 and osteoblastic differentiation, suggesting the involvement of AMPK. | trelagliptin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |