Protein Name secreted phosphoprotein 1
Organism Homo sapiens
Gene ID 6696
Gene Symbol


UniProt P10451 (OSTP_HUMAN), A0A024RDE2 (A0A024RDE2_HUMAN), B7Z351 (B7Z351_HUMAN), A0A024RDJ0 (A0A024RDJ0_HUMAN), A0A024RDE6 (A0A024RDE6_HUMAN), Q3LGB0 (Q3LGB0_HUMAN)
Relationships Total Number of functionally related compound(s) : 1527
Total Number of Articles : 1668

secreted phosphoprotein 1

Gene Summary

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

  • osteopontin
  • SPP1/CALPHA1 fusion
  • early T-lymphocyte activation 1
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