Protein Name RUNX family transcription factor 2
Organism Homo sapiens
Gene ID 860
Gene Symbol

RUNX2

UniProt Q13950 (RUNX2_HUMAN), Q32MY8 (Q32MY8_HUMAN), A0A0D9SEN7 (A0A0D9SEN7_HUMAN)
Relationships Total Number of functionally related compound(s) : 661
Total Number of Articles : 987
Description

RUNX family transcription factor 2

Gene Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]

synonyms
  • runt-related transcription factor 2
  • PEA2-alpha A
  • PEBP2-alpha A
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Properties