| Protein Name | bone morphogenetic protein 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 650 |
| Gene Symbol | BMP2 |
| UniProt | P12643 (BMP2_HUMAN), C8C060 (C8C060_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
860
Total Number of Articles : 1406 |
Description |
bone morphogenetic protein 2 |
| Gene Summary |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016] |
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