Protein Name bone morphogenetic protein 2
Organism Homo sapiens
Gene ID 650
Gene Symbol


UniProt P12643 (BMP2_HUMAN), C8C060 (C8C060_HUMAN)
Relationships Total Number of functionally related compound(s) : 860
Total Number of Articles : 1406

bone morphogenetic protein 2

Gene Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]

  • bone morphogenetic protein 2
  • bone morphogenetic protein 2A
  • BDA2
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