Protein Name alkaline phosphatase, placental
Organism Homo sapiens
Gene ID 250
Gene Symbol


UniProt P05187 (PPB1_HUMAN), B2R7C7 (B2R7C7_HUMAN)
Relationships Total Number of functionally related compound(s) : 1677
Total Number of Articles : 2219

alkaline phosphatase, placental

Gene Summary

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Aug 2020]

  • alkaline phosphatase, placental type
  • Intestinal alkaline phosphatase
  • Intestinal-type alkaline phosphatase
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