Pub. Date : 2019 Jan
PMID : 30353642
19 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. | CUDC-907 | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. | CUDC-907 | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 3 | CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. | CUDC-907 | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. | CUDC-907 | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. | CUDC-907 | BCL2 apoptosis regulator | Homo sapiens |
| 6 | CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. | CUDC-907 | BCL2 apoptosis regulator | Homo sapiens |
| 7 | CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. | CUDC-907 | BCL2 like 1 | Homo sapiens |
| 8 | CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. | CUDC-907 | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 9 | Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. | CUDC-907 | TNF superfamily member 13b | Homo sapiens |
| 10 | Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. | CUDC-907 | TNF receptor superfamily member 13C | Homo sapiens |
| 11 | Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. | CUDC-907 | TNF receptor superfamily member 13B | Homo sapiens |
| 12 | Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. | CUDC-907 | TNF receptor superfamily member 17 | Homo sapiens |
| 13 | Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. | CUDC-907 | TNF superfamily member 13b | Homo sapiens |
| 14 | Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. | CUDC-907 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 15 | T cell chemokines CCL3/4/17/22 and phosphorylation of CXCR4 were also reduced by CUDC-907. | CUDC-907 | C-C motif chemokine ligand 3 | Homo sapiens |
| 16 | T cell chemokines CCL3/4/17/22 and phosphorylation of CXCR4 were also reduced by CUDC-907. | CUDC-907 | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 17 | Indeed, combinations of low concentrations of CUDC-907 with inhibitors of BCL2, BTK, or the NF-kappaB pathway showed a potent synergistic effect. | CUDC-907 | BCL2 apoptosis regulator | Homo sapiens |
| 18 | Indeed, combinations of low concentrations of CUDC-907 with inhibitors of BCL2, BTK, or the NF-kappaB pathway showed a potent synergistic effect. | CUDC-907 | Bruton tyrosine kinase | Homo sapiens |
| 19 | Indeed, combinations of low concentrations of CUDC-907 with inhibitors of BCL2, BTK, or the NF-kappaB pathway showed a potent synergistic effect. | CUDC-907 | nuclear factor kappa B subunit 1 | Homo sapiens |