PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30353642-4 2019 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 0-8 AKT serine/threonine kinase 1 Homo sapiens 24-27 30353642-4 2019 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 0-8 mitogen-activated protein kinase kinase 7 Homo sapiens 84-87 30353642-4 2019 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 0-8 mitogen-activated protein kinase 1 Homo sapiens 88-91 30353642-4 2019 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 0-8 signal transducer and activator of transcription 3 Homo sapiens 96-101 30353642-4 2019 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 0-8 BCL2 apoptosis regulator Homo sapiens 158-163 30353642-4 2019 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 0-8 BCL2 apoptosis regulator Homo sapiens 180-185 30353642-4 2019 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 0-8 BCL2 like 1 Homo sapiens 187-193 30353642-4 2019 CUDC-907 inhibited PI3K/AKT and HDAC activity, as expected, but also suppressed RAF/MEK/ERK and STAT3 signalling and reduced the expression of anti-apoptotic BCL-2 family proteins BCL-2, BCL-xL, and MCL-1. CUDC-907 0-8 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 199-204 30353642-5 2019 Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. CUDC-907 10-18 TNF superfamily member 13b Homo sapiens 43-47 30353642-5 2019 Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. CUDC-907 10-18 TNF receptor superfamily member 13C Homo sapiens 78-83 30353642-5 2019 Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. CUDC-907 10-18 TNF receptor superfamily member 13B Homo sapiens 85-89 30353642-5 2019 Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. CUDC-907 10-18 TNF receptor superfamily member 17 Homo sapiens 95-99 30353642-5 2019 Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. CUDC-907 10-18 TNF superfamily member 13b Homo sapiens 78-82 30353642-5 2019 Moreover, CUDC-907 downregulated cytokines BAFF and APRIL and their receptors BAFFR, TACI, and BCMA, thus blocking BAFF-induced NF-kappaB signalling. CUDC-907 10-18 nuclear factor kappa B subunit 1 Homo sapiens 128-137 30353642-6 2019 T cell chemokines CCL3/4/17/22 and phosphorylation of CXCR4 were also reduced by CUDC-907. CUDC-907 81-89 C-C motif chemokine ligand 3 Homo sapiens 18-30 30353642-6 2019 T cell chemokines CCL3/4/17/22 and phosphorylation of CXCR4 were also reduced by CUDC-907. CUDC-907 81-89 C-X-C motif chemokine receptor 4 Homo sapiens 54-59 30353642-8 2019 Indeed, combinations of low concentrations of CUDC-907 with inhibitors of BCL2, BTK, or the NF-kappaB pathway showed a potent synergistic effect. CUDC-907 46-54 BCL2 apoptosis regulator Homo sapiens 74-78 30353642-8 2019 Indeed, combinations of low concentrations of CUDC-907 with inhibitors of BCL2, BTK, or the NF-kappaB pathway showed a potent synergistic effect. CUDC-907 46-54 Bruton tyrosine kinase Homo sapiens 80-83 30353642-8 2019 Indeed, combinations of low concentrations of CUDC-907 with inhibitors of BCL2, BTK, or the NF-kappaB pathway showed a potent synergistic effect. CUDC-907 46-54 nuclear factor kappa B subunit 1 Homo sapiens 92-101