Lysine

serpin family C member 1 ; Homo sapiens







33 Article(s)
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1 21875153 Energetics of hydrogen bond switch, residue burial and cavity analysis reveals molecular basis of improved heparin binding to antithrombin. 2011 Oct 4
2 19661062 The signature 3-O-sulfo group of the anticoagulant heparin sequence is critical for heparin binding to antithrombin but is not required for allosteric activation. 2009 Oct 2 3
3 19689280 Structure-activity relationships of low molecular weight heparins expose to the risk of achieving inappropriate targets in patients with renal failure. 2009 3
4 18206177 Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteine. 2008 Feb 13 1
5 12556442 Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and its conformational activation. 2003 May 2 1
6 11741963 Helix D elongation and allosteric activation of antithrombin. 2002 Mar 8 1
7 11939772 Importance of lysine 125 for heparin binding and activation of antithrombin. 2002 Apr 16 1
8 12022882 Role of basic residues of the autolysis loop in the catalytic function of factor Xa. 2002 May 28 1
9 12161073 Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants. 2002 Jul 3
10 12353073 Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity. 2002 Sep 1
11 12369826 Specificity of the basic side chains of Lys114, Lys125, and Arg129 of antithrombin in heparin binding. 2002 Oct 15 1
12 11567021 Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding. 2001 Nov 23 1
13 10766996 Novel mutation (E113X) of antithrombin III gene (AT3) in a woman with gestational recurrent thrombosis. 2000 Apr 24 1
14 10850803 Role of Lys335 in the metastability and function of inhibitory serpins. 2000 May 1
15 10974350 Plasminogen and tissue plasminogen activator interact with antithrombin III. 2000 Sep 15 3
16 9692954 Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site. 1998 Jul 28 1
17 9763552 Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation. 1998 Oct 15 4
18 9065421 Lysine residue 114 in human antithrombin III is required for heparin pentasaccharide-mediated activation. 1997 Mar 21 3
19 9235938 Identification of the antithrombin III heparin binding site. 1997 Aug 1 2
20 8702852 Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III. 1996 Aug 23 1
21 8910598 Role of arginine 132 and lysine 133 in heparin binding to and activation of antithrombin. 1996 Nov 15 1
22 7947827 Lysine-heparin interactions in antithrombin. Properties of K125M and K290M,K294M,K297M variants. 1994 Nov 29 2
23 8288594 Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III. 1994 Jan 14 1
24 2229057 Important role of arginine 129 in heparin-binding site of antithrombin III. Identification of a novel mutation arginine 129 to glutamine. 1990 Nov 5 3
25 2478364 The heparin and pentosan polysulfate binding sites of human antithrombin overlap but are not identical. 1989 Oct 20 3
26 2492530 Binding of heparin to human antithrombin III activates selective chemical modification at lysine 236. Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of antithrombin III. 1989 Feb 25 24
27 3110143 Identification of a lysyl residue in antithrombin which is essential for heparin binding. 1987 Jun 15 3
28 3121595 The heparin binding site of human antithrombin III. Selective chemical modification at Lys114, Lys125, and Lys287 impairs its heparin cofactor activity. 1987 Dec 25 2
29 3095926 Acetylation of antithrombin III by aspirin. 1986 Jul 1
30 6420409 Pyridoxylation of essential lysines in the heparin-binding site of antithrombin III. 1984 Jan 25 3
31 6698980 Predictions of the secondary structure of antithrombin III and the location of the heparin-binding site. 1984 Feb 25 1
32 6462134 Kinetic analysis of the heparin-enhanced plasmin--antithrombin III reaction. Apparent catalytic role of heparin. 1981 Dec 1 1
33 849484 The aggregation of basic polypeptide residues bound to heparin. 1977 Mar 29 1