Title : Identification of a lysyl residue in antithrombin which is essential for heparin binding.

Pub. Date : 1987 Jun 15

PMID : 3110143






3 Functional Relationships(s)
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1 Modification of antithrombin with limiting amounts of reagent yields an average incorporation of the phosphopyridoxyl label into 1 lysine/protein molecule (Pecon, J. M., and Blackburn, M. N. (1984) J. Biol. Lysine serpin family C member 1 Homo sapiens
2 This peptide corresponds to a tryptic fragment including residues 115-129 in the sequence of antithrombin, with the modified residue identified as Lys-125. Lysine serpin family C member 1 Homo sapiens
3 Identification of this critical lysine for heparin binding strongly supports previous data which indicate that the heparin-binding domain of antithrombin is located at the NH2 terminus within one of the disulfide cross-linked loops of the protein. Lysine serpin family C member 1 Homo sapiens