Title : Plasminogen and tissue plasminogen activator interact with antithrombin III.

Pub. Date : 2000 Sep 15

PMID : 10974350






3 Functional Relationships(s)
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1 The interaction of plasminogen was significantly (>90%) inhibited by lysine, indicating the involvement of kringles in binding antithrombin III. Lysine serpin family C member 1 Homo sapiens
2 Using carboxypeptidase B digestion, the plasminogen-binding site of antithrombin III was localized to the carboxy-terminus lysine of the anticoagulant protein. Lysine serpin family C member 1 Homo sapiens
3 Tissue plasminogen activator also interacted with antithrombin III in a time- and concentration-dependent manner and its binding was also significantly (>90%) inhibited by lysine. Lysine serpin family C member 1 Homo sapiens