Title : Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III.

Pub. Date : 1994 Jan 14

PMID : 8288594






1 Functional Relationships(s)
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1 Point mutations at Arg-180, Arg-245, Lys-248, and Lys-252 in thrombin markedly reduced the efficiency of heparin catalysis by decreasing the stability of the ternary intermediate, whereas the inactivation of thrombin by antithrombin alone was not affected by these mutations. Lysine serpin family C member 1 Homo sapiens