Steroids

cytochrome P450 family 17 subfamily A member 1 ; Homo sapiens







222 Article(s)
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1 35085884 Integrated assessment of endocrine disrupting potential of four novel brominated flame retardants. 2022 Mar 1 1
2 35087285 Association Between the Polymorphism of Steroid Hormone Metabolism Genes and High-Altitude Pulmonary Edema in the Chinese Han Population. 2022 1
3 35132941 Synthesis, molecular docking, molecular dynamics and evaluation of Drug-Likeness properties of the fused N-Formyl pyrazoline substituted new dehydroepiandrosterone derivatives. 2022 Feb 8 1
4 35287432 Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1. 2022 Apr 5 2
5 32456493 CYP17 gene polymorphic sequence variation is associated with hyperandrogenism in Kashmiri women with polycystic ovarian syndrome. 2021 Mar 1
6 33436964 Gene expression and functional abnormalities in XX/Sry Leydig cells. 2021 Jan 12 1
7 33753170 Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis. 2021 Jan-Jun 1
8 33844306 Analysis of astaxanthin molecular targets based on network pharmacological strategies. 2021 May 1
9 34538754 The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis. 2021 Nov 1
10 34563259 The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis. 2021 Sep 26 1
11 31691616 A rare enzymatic defect, true isolated 17,20-lyase deficiency leading to endocrine disorders and infertility: case report. 2020 Apr 1
12 32007561 CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. 2020 May 2
13 32516371 Biochemical, Histopathological, and Genetic Characterization of Posture-Responsive and Unresponsive APAs. 2020 Sep 1 1
14 32530640 Comparative Dynamics and Functional Mechanisms of the CYP17A1 Tunnels Regulated by Ligand Binding. 2020 Jul 27 1
15 32660148 Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents. 2020 Jul 9 1
16 33780934 Genotypic Sex and Severity of the Disease Determine the Time of Clinical Presentation in Steroid 17α-Hydroxylase/17,20-Lyase Deficiency. 2020 1
17 30825506 The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis. 2019 May 2
18 31031706 The Effect of Soy Isoflavones on Steroid Metabolism. 2019 1
19 31039398 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro. 2019 Jul 3
20 31072872 Conformational selection dominates binding of steroids to human cytochrome P450 17A1. 2019 Jun 28 1
21 31150682 Steroidogenic potential of human fetal kidney at early gestational age. 2019 Sep 1
22 31169883 Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. 2019 Nov 1 1
23 31207124 Impact of hormonal contraceptives on urinary steroid profile in relation to serum hormone changes and CYP17A1 polymorphism. 2019 Sep 1
24 31330226 The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax. 2019 Sep 1 1
25 31356544 CYP17A1 Polymorphisms Are Linked to the Risk of Coronary Heart Disease in a Case-Control Study. 2019 Aug 2
26 31509771 Effect of mutations in porcine CYB5A and CYP17A1 on the metabolism of pregnenolone. 2019 Dec 2
27 29338791 Associations of the hypertension-related single nucleotide polymorphism rs11191548 with high-density lipoprotein cholesterol and leptin in Chinese children. 2018 Jan 16 1
28 29710837 Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency. 2018 Apr 29 1
29 29880207 Corrigendum to "Comparison of [17(20)E]-21-Norpregnene oxazolinyl and benzoxazolyl derivatives as inhibitors of CYP17A1 activity and prostate carcinoma cells growth" [Steroids 129 (2018) 24-34]. 2018 Aug 1
30 29888793 Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step. 2018 Jul 2
31 29942286 A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese. 2018 2
32 30066910 A random forest classifier predicts recurrence risk in patients with ovarian cancer. 2018 Sep 2
33 26862015 Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic. 2017 Jan 2
34 27566228 Structural insights into the function of steroidogenic cytochrome P450 17A1. 2017 Feb 5 2
35 28272372 ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure. 2017 Mar 7 1
36 28373265 Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. 2017 Jun 1
37 28389510 Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer. 2017 Aug 15 1
38 28609197 The Glu331del mutation in the CYP17A1 gene causes atypical congenital adrenal hyperplasia in a 46,XX female. 2017 Dec 1
39 28684414 Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. 2017 Aug 11 1
40 28786422 Prostate cancer: The influence of steroid metabolism on CYP17A1 inhibitor activity. 2017 Oct 1
41 28890368 CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. 2017 Nov 2
42 28992603 Sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering. 2017 Dec 1
43 26297028 CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study. 2016 Apr 1
44 26432395 Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution. 2016 Jan 1
45 26704533 Preliminary evidence of altered steroidogenesis in women with Alzheimer's disease: Have the patients "OLDER" adrenal zona reticularis? 2016 Apr 2
46 26781511 High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells. 2016 Apr 1
47 26902494 Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus. 2016 Apr 1
48 27083183 The CYP17A1 inhibitor abiraterone exhibits estrogen receptor agonist activity in breast cancer. 2016 May 2
49 27217499 Acetaminophen Increases Aldosterone Secretion While Suppressing Cortisol and Androgens: A Possible Link to Increased Risk of Hypertension. 2016 Oct 1
50 24832628 3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging. 2015 1