Title : The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax.

Pub. Date : 2019 Sep 1

PMID : 31330226






1 Functional Relationships(s)
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1 Clotrimazole inhibited steroid production in a dose-dependent manner with IC50 values for CYP17A1 and CYP19A1 in the range 0.017-0.184 muM. Steroids cytochrome P450 family 17 subfamily A member 1 Homo sapiens