PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24832628-1 2015 Androstenedione is a common precursor of sex steroids produced and secreted in the human adrenal gland and produced by 3beta-hydroxysteroid dehydrogenase (3betaHSD), 17beta-hydroxylase/17,20-lyase (CYP17) and cytochrome b5 (CYB5A). Steroids 45-53 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 198-203 25765894-2 2015 CYP17A1 is a key enzyme in the biosynthesis of adrenal and gonadal steroid hormones facilitating both 17alpha-hydroxylase and 17,20-lyase activities. Steroids 67-83 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 25301938-3 2014 CYP17A1 structures with all four physiologically relevant steroid substrates suggest answers to four fundamental aspects of CYP17A1 function. Steroids 58-65 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 25301938-3 2014 CYP17A1 structures with all four physiologically relevant steroid substrates suggest answers to four fundamental aspects of CYP17A1 function. Steroids 58-65 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 124-131 24971814-5 2014 Docking of aforementioned compounds to CYP17A1 revealed that steroid fragments of compound 1 and abiraterone 3 occupied close positions; oxazoline cycle of compound 1 was coordinated with heme iron similarly to pyridine cycle of abiraterone 3. Steroids 61-68 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 39-46 25038322-6 2014 A higher Km- and a lower kcat-value for CYP17A1 using PregS compared with Preg were observed, indicating a 40% reduced catalytic efficiency when using the sulfonated steroid. Steroids 166-173 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 40-47 25038322-9 2014 When using human SOAT-HEK293 cells expressing CYP17A1 and CPR, we could confirm that PregS is metabolized to 17OH-PregS, strengthening the potential physiological meaning of a pathway for sulfonated steroids. Steroids 199-207 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 46-53 23752196-5 2014 Phase III clinical trials showing a survival advantage in CRPC for treatment with abiraterone (inhibitor of the enzyme CYP17A1 required for androgen synthesis that markedly reduces androgens and precursor steroids) and for enzalutamide (new AR antagonist) have now confirmed that AR activity driven by residual androgens makes a major contribution to CRPC, and led to the recent Food and Drug Administration approval of both agents. Steroids 205-213 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 119-126 25012481-0 2014 Association study of two steroid biosynthesis genes (COMT and CYP17) with Alzheimer"s disease in the Italian population. Steroids 25-32 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 62-67 24456285-0 2014 An innovative LC-MS/MS-based method for determining CYP 17 and CYP 19 activity in the adipose tissue of pre- and postmenopausal and ovariectomized women using 13C-labeled steroid substrates. Steroids 171-178 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-58 24610083-7 2014 This steroid secretion pattern can be explained by the demonstrated inhibition of CYP17A1 enzyme activity. Steroids 5-12 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 82-89 24456285-12 2014 CONCLUSION: Our findings suggest that adipose tissue acts as an endocrine organ, with CYP17 and CYP19 activity playing an essential role in sex steroid hormone biosynthesis. Steroids 144-159 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 86-91 24299954-1 2014 Cytochrome P450 CYP17A1 catalyzes a series of reactions that lie at the intersection of corticoid and androgen biosynthesis and thus occupies an essential role in steroid hormone metabolism. Steroids 163-178 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 16-23 24485502-1 2014 CYP17A1 catalyzes the 17-hydroxylase and 17,20-lyase reactions, regulating the steroid hormones produced by the adrenal glands and gonads. Steroids 79-95 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 24681790-2 2014 The CYP17 gene encodes the enzyme cytochrome P450c17, which functions at key steps during the process of human sex steroid hormone synthesis. Steroids 115-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-9 24681790-2 2014 The CYP17 gene encodes the enzyme cytochrome P450c17, which functions at key steps during the process of human sex steroid hormone synthesis. Steroids 115-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-52 24007292-2 2014 The inhibition of steroid 17alpha-hydroxylase/17,20- lyase (CYP17), which is a crucial enzyme for steroid hormone biosynthesis, is widely used to treat androgen-dependent prostate cancer (PC). Steroids 98-113 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 18-58 24007292-2 2014 The inhibition of steroid 17alpha-hydroxylase/17,20- lyase (CYP17), which is a crucial enzyme for steroid hormone biosynthesis, is widely used to treat androgen-dependent prostate cancer (PC). Steroids 98-113 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 60-65 24007292-3 2014 CYP17 has dual enzymatic activity: 17alpha-hydroxylase activity (utilizing delta4- C21 steroids as substrates) and the 17,20-lyase activity (using delta5- C21 steroids as substrates). Steroids 87-95 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 24007292-3 2014 CYP17 has dual enzymatic activity: 17alpha-hydroxylase activity (utilizing delta4- C21 steroids as substrates) and the 17,20-lyase activity (using delta5- C21 steroids as substrates). Steroids 159-167 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 24007292-4 2014 The steroid biosynthetic pathway is directed to either the production of corticosteroids or sex hormones depending on the activity of CYP17. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 134-139 24276076-1 2014 As the first in class steroid 17alpha-hydroxylase/C17,20-lyase (CYP17) inhibitor, abiraterone acetate (of which the active metabolite is abiraterone) has been shown to improve overall survival in patients with castration-resistant prostate cancer (CRPC)--in those who are chemotherapy-naive and those previously treated with docetaxel. Steroids 22-29 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-69 23836902-1 2013 Cytochrome P450c17, a steroidogenic enzyme encoded by the CYP17A1 gene, catalyzes the steroid 17alpha-hydroxylation needed for glucocorticoid synthesis, which may or may not be followed by 17,20 lyase activity needed for sex steroid synthesis. Steroids 22-29 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 24205838-1 2013 Cytochrome P450 (CYP) 17A1 is a dual-function monooxygenase with a critical role in the synthesis of many human steroid hormones. Steroids 112-128 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-26 24314739-3 2013 RESULTS: Inhibition of CYP17A1 with abiraterone acetate induces changes in steroid metabolism, whose main component is the reduction of DHEA and androstenedione synthesis. Steroids 75-82 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 23-30 23836902-1 2013 Cytochrome P450c17, a steroidogenic enzyme encoded by the CYP17A1 gene, catalyzes the steroid 17alpha-hydroxylation needed for glucocorticoid synthesis, which may or may not be followed by 17,20 lyase activity needed for sex steroid synthesis. Steroids 86-93 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 58-65 23836902-1 2013 Cytochrome P450c17, a steroidogenic enzyme encoded by the CYP17A1 gene, catalyzes the steroid 17alpha-hydroxylation needed for glucocorticoid synthesis, which may or may not be followed by 17,20 lyase activity needed for sex steroid synthesis. Steroids 22-29 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 58-65 23836902-1 2013 Cytochrome P450c17, a steroidogenic enzyme encoded by the CYP17A1 gene, catalyzes the steroid 17alpha-hydroxylation needed for glucocorticoid synthesis, which may or may not be followed by 17,20 lyase activity needed for sex steroid synthesis. Steroids 86-93 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 22817457-0 2012 Mechanism of intermolecular interactions of microsomal cytochrome P450s CYP17 and CYP21 involved in steroid hormone biosynthesis. Steroids 100-115 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 72-77 23015357-3 2013 Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Steroids 152-159 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 118-125 22954317-9 2013 MAIN OUTCOME MEASURES: The CYP17A1 gene was sequenced and we measured steroid and sex hormone levels. Steroids 70-77 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 27-34 22048715-1 2012 CYP17A1 gene encodes the cytochrome P450 enzyme CYP17A1, a key enzyme involved in steroid metabolism. Steroids 82-89 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 22048715-1 2012 CYP17A1 gene encodes the cytochrome P450 enzyme CYP17A1, a key enzyme involved in steroid metabolism. Steroids 82-89 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 48-55 22924551-7 2012 (2005) discovered new, potent inhibitors of CYP17 (C-17 steroid derivatives) with pure AR antagonistic properties. Steroids 56-63 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 44-49 22778212-4 2012 Androgen biosynthesis requires steroid enzymes 17alpha-Hydroxylase/17,20 lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase type 2 (HSD3B2), which are overexpressed in ovarian cells of polycystic ovary syndrome women. Steroids 31-38 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 80-87 23620596-3 2013 CYP17A1 performs both steroid hydroxylation, which is unaffected by b5, and an androgen-forming lyase reaction that is facilitated 10-fold by b5. Steroids 22-29 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 23415678-1 2013 The steroidogenic cytochrome P450 17 (CYP17) enzyme produces dehydroepiandrosterone (DHEA), which is the most abundant circulating endogenous sex steroid precursor. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 18-36 23415678-1 2013 The steroidogenic cytochrome P450 17 (CYP17) enzyme produces dehydroepiandrosterone (DHEA), which is the most abundant circulating endogenous sex steroid precursor. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 38-43 23586722-1 2013 CYP17 (steroid 17alpha-hydroxylase/17,20-lyase) is a key enzyme in steroid hormone biosynthesis. Steroids 67-82 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 23586722-1 2013 CYP17 (steroid 17alpha-hydroxylase/17,20-lyase) is a key enzyme in steroid hormone biosynthesis. Steroids 67-82 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 7-46 22336992-3 2012 We investigated maternal functional polymorphisms of CYP17, CYP19, and CYP1B1, which control three major enzymatic steps in sex steroid biosynthesis and metabolism, in relation to childhood behaviors. Steroids 128-135 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 53-58 22170710-10 2012 Detailed review of previously reported cases with apparently isolated 17,20 lyase deficiency due to mutant CYP17A1 and POR reveals impaired 17alpha-hydroxylase activity as assessed by steroid metabolome analysis and short cosyntropin testing. Steroids 184-191 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 107-114 22025366-6 2012 Genes involved downstream in steroid hormone generation, including CYP17A1 and CYP19A1 were also induced. Steroids 29-44 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 67-74 21824047-2 2012 This study aimed to correlate polymorphisms of genes involved in the biosynthesis and metabolism of steroids and insulin action (CYP17A1, CYP19A1, AR, ESR1, ESR2, INSR, IGF2 and PAI1) with clinical and biochemical parameters of PCOS. Steroids 100-108 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 129-136 22064602-5 2012 The generation of DHT occurs in large part from adrenal 19-carbon precursor steroids, which are dependent on expression of CYP17A1. Steroids 76-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 123-130 22222232-5 2012 This result not only validated a new therapy for CRPC but also, with the antecedent phase I-II abiraterone studies, shattered our understanding of the molecular mechanisms underpinning CRPC development and progression.Aromatase inhibitors and CYP17A1 inhibitors will be widely used by oncologists, yet fellowship programs provide little training in steroid biosynthesis, compared with training in the biology of standard chemotherapies. Steroids 349-356 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 243-250 22170708-4 2012 RESULTS: Treatment with single-agent abiraterone acetate was associated with accumulation of steroids with mineralocorticoid properties upstream of CYP17A1. Steroids 93-101 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 148-155 22024430-5 2012 The mathematical model developed in this study simulates the network of reactions catalyzed by 3beta-HSD and P450c17 that characterizes steroid synthesis in human, non-human primate, ovine, and bovine species. Steroids 136-143 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 109-116 22266943-2 2012 As prostate cancer cells proliferate in response to androgen steroids, CYP17A1 inhibition is a new strategy to prevent androgen synthesis and treat lethal metastatic castration-resistant prostate cancer, but drug development has been hampered by lack of information regarding the structure of CYP17A1. Steroids 61-69 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 71-78 22975514-0 2012 Inhibition of human steroidogenic cytochrome P450 c17 by 21-hydroxypregnenolone and related steroid hormones. Steroids 92-108 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 34-53 22975514-5 2012 These results suggest that a hydroxyl group at C3 in the A ring and a double bond at C5 in the B ring in steroid hormones are important for the substrate recognition of CYP17. Steroids 105-121 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 169-174 23110082-1 2012 BACKGROUND: The objective of the study was to investigate the role of genes (HSD3B1, CYP17A1, CYP19A1, HSD17B2, HSD17B1) involved in the steroid hormone biosynthesis pathway and progesterone receptor (PGR) in the etiology of gastric cancer in a population-based two-phase genetic association study. Steroids 137-152 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 85-92 21868758-8 2011 Together, our results indicate that CRPCs resistant to CYP17A1 inhibition may remain steroid dependent and therefore responsive to therapies that can further suppress de novo intratumoral steroid synthesis. Steroids 85-92 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 55-62 21868758-0 2011 Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Steroids 21-28 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 144-151 21193363-2 2011 Two key steps in the sex steroid synthesis are mediated by the enzyme cytochrome P450c 17alpha which is encoded in the CYP17 gene. Steroids 25-32 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 70-94 21193363-2 2011 Two key steps in the sex steroid synthesis are mediated by the enzyme cytochrome P450c 17alpha which is encoded in the CYP17 gene. Steroids 25-32 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 119-124 20619364-0 2011 At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17. Steroids 21-36 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 115-120 21586563-6 2011 Using progesterone as substrate for bacterially expressed purified human P450c17, the Michaelis constant for 17alpha-hydroxylase activity supported by N-27 POR or N-27 POR-G3H6 were 1.73 or 1.49 mum, and the maximal velocity was 0.029 or 0.026 pmol steroids per picomole P450 per minute, respectively. Steroids 249-257 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 73-80 21586563-7 2011 Using 17-hydroxypregnenolone as the P450c17 substrate, the Michaelis constant for 17,20 lyase activity using N-27 POR or N-27 POR-G3H6 was 1.92 or 1.89 mum and the maximal velocity was 0.041 or 0.042 pmol steroid per picomole P450 per minute, respectively. Steroids 205-212 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 36-43 21948762-0 2011 Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey. Steroids 25-32 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 70-75 21307141-9 2011 Baseline levels of CYP17 steroid products were higher in primary cells and significantly increased in the presence of 22-hydroxycholesterol. Steroids 25-32 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 19-24 21282350-0 2011 A unique exonic splicing mutation in the CYP17A1 gene as the cause for steroid 17{alpha}-hydroxylase deficiency. Steroids 71-78 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 41-48 20069306-1 2011 PURPOSE: The CYP17 gene encodes the enzyme cytochrome P450c17alpha, which functions at key steps in the synthesis process of human sex steroid hormones. Steroids 135-151 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 13-18 20069306-1 2011 PURPOSE: The CYP17 gene encodes the enzyme cytochrome P450c17alpha, which functions at key steps in the synthesis process of human sex steroid hormones. Steroids 135-151 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-66 20619364-4 2011 CYP17 catalyzes the 17alpha-hydroxylation reaction of delta4-C21 steroids (progesterone derivatives) and delta5-C21 steroids (pregnenolone derivatives) as well as the 17,20-lyase reaction producing C19-steroids, a key branch point in steroid hormone biosynthesis. Steroids 65-73 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 20619364-4 2011 CYP17 catalyzes the 17alpha-hydroxylation reaction of delta4-C21 steroids (progesterone derivatives) and delta5-C21 steroids (pregnenolone derivatives) as well as the 17,20-lyase reaction producing C19-steroids, a key branch point in steroid hormone biosynthesis. Steroids 116-124 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 20619364-4 2011 CYP17 catalyzes the 17alpha-hydroxylation reaction of delta4-C21 steroids (progesterone derivatives) and delta5-C21 steroids (pregnenolone derivatives) as well as the 17,20-lyase reaction producing C19-steroids, a key branch point in steroid hormone biosynthesis. Steroids 201-210 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 20619364-4 2011 CYP17 catalyzes the 17alpha-hydroxylation reaction of delta4-C21 steroids (progesterone derivatives) and delta5-C21 steroids (pregnenolone derivatives) as well as the 17,20-lyase reaction producing C19-steroids, a key branch point in steroid hormone biosynthesis. Steroids 234-249 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 20619364-5 2011 Depending on CYP17 activity, the steroid hormone biosynthesis pathway is directed to either the formation of mineralocorticoids and glucocorticoids or sex hormones. Steroids 33-48 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 13-18 20729792-1 2010 OBJECTIVE: Catechol-O-methyltransferase (COMT) and cytochrome P450c17alpha (CYP17A1) are key enzymes involved in the metabolism of steroid hormones; genetic polymorphisms in these genes affect enzyme activity. Steroids 131-147 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 51-74 20729792-1 2010 OBJECTIVE: Catechol-O-methyltransferase (COMT) and cytochrome P450c17alpha (CYP17A1) are key enzymes involved in the metabolism of steroid hormones; genetic polymorphisms in these genes affect enzyme activity. Steroids 131-147 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 76-83 21338212-1 2010 The human CYP17 gene, located on chromosome 10q24.3, plays a key role in sex steroid synthesis, mainly related to estrogen. Steroids 77-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 10-15 19508587-3 2010 However, little remains known about steroid biosynthetic functions in carriers with these mutations in a single allele of the CYP17A1 gene, who are assumed to have 50% P450c17 activity. Steroids 36-43 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 126-133 19508587-12 2010 CONCLUSION: Genotype-proven carriers of the CYP17A1 mutation who lack apparent clinical symptoms exhibit decreased adrenal 17alpha-hydroxylase activity and altered adrenal gland reserve for steroid biosynthesis. Steroids 190-197 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 44-51 20080843-1 2010 CONTEXT: Cytochrome P450c17 (P450c17) is a bifunctional enzyme necessary for the production of glucocorticoids (17-hydroxylase activity) and sex steroids (17,20-lyase activity). Steroids 145-153 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-27 20080843-1 2010 CONTEXT: Cytochrome P450c17 (P450c17) is a bifunctional enzyme necessary for the production of glucocorticoids (17-hydroxylase activity) and sex steroids (17,20-lyase activity). Steroids 145-153 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 29-36 20160131-2 2010 The ratio of lyase to hydroxylase activity of human P450c17 determines whether steroidogenesis leads to the synthesis of cortisol or sex steroids. Steroids 137-145 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-59 20113968-2 2010 In this regard, the cytochrome subfamily 17 (CYP17) may play an important role by altering the biosynthesis of sex steroids. Steroids 115-123 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-50 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Steroids 186-201 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 151-158 19443382-1 2009 BACKGROUND: The CYP17 gene codes for the cytochrome P450c17a enzyme, which mediates two key steps in sex steroid synthesis In this study, the association between CYP17 polymorphism and the risk of prostate cancer in comparison to benign prostatic hyperplasia (BPH) in a north Indian population was investigated. Steroids 105-112 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 16-21 19598235-12 2009 In the sex steroid group, this included CYP17A1 and CYP19A1. Steroids 11-18 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 40-47 19443382-1 2009 BACKGROUND: The CYP17 gene codes for the cytochrome P450c17a enzyme, which mediates two key steps in sex steroid synthesis In this study, the association between CYP17 polymorphism and the risk of prostate cancer in comparison to benign prostatic hyperplasia (BPH) in a north Indian population was investigated. Steroids 105-112 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 41-59 19443382-1 2009 BACKGROUND: The CYP17 gene codes for the cytochrome P450c17a enzyme, which mediates two key steps in sex steroid synthesis In this study, the association between CYP17 polymorphism and the risk of prostate cancer in comparison to benign prostatic hyperplasia (BPH) in a north Indian population was investigated. Steroids 105-112 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 162-167 19500762-4 2009 Defects of steroid 21-hydroxylase (CYP21A2) and 11beta-hydroxylase (CYP11B1) only affect adrenal steroidogenesis, whereas 17alpha-hydroxylase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase type 2 (HSD3B2) deficiency also impact on gonadal steroid biosynthesis. Steroids 11-18 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 143-150 18645709-2 2008 It is well established that endogenous sex hormones are involved in disease pathogenesis, and polymorphisms in genes encoding enzymes which act in the metabolism of steroid hormones, such as that for cytochrome P450c17alpha enzyme (CYP17), may therefore play a role in fibroid genesis. Steroids 165-181 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 200-230 18996963-1 2009 OBJECTIVE: 17-Hydroxylase/17,20-lyase deficiency (17OHD) results from mutations in the CYP17A1 gene, leading to failure to synthesize cortisol, adrenal androgens, and gonadal steroids. Steroids 175-183 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 87-94 18645193-7 2008 Abiraterone acetate administration was associated with increased levels of adrenocorticotropic hormone and steroids upstream of CYP17 and with suppression of serum testosterone, downstream androgenic steroids, and estradiol in all patients. Steroids 107-115 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 128-133 18619560-3 2008 Inhibiting the systemic biosynthesis of androgens in CRPC by targeting CYP17 may thus represent a rational therapeutic approach since this enzyme catalyses two key steroid reactions involving 17alpha-hydroxylase and C(17,20)-lyase in the androgen biosynthesis pathway. Steroids 164-171 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 71-76 18707589-1 2008 To engineer a "soluble" form of membrane-bound cytochrome P45017alpha (CYP17)--a key enzyme in steroid hormone biosynthesis--in the present work we have built a computer model of the tertiary structure of the hemeprotein, identified the surface hydrophobic amino acid residues, substituted these residues for more hydrophilic ones, and expressed and purified hydrophilized forms of CYP17. Steroids 95-110 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 71-76 18821018-5 2009 Qualitative regulation, which determines the type of steroid produced in a cell, is principally at the level of P450c17 (CYP17). Steroids 53-60 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 112-119 19101629-2 2009 Cytochrome P450C17 (CYP17A1) catalyses the key regulatory step in the formation of the 16-androstene steroids from pregnenolone by the andien-beta synthase reaction or the synthesis of the glucocorticoid and sex steroids via 17alpha-hydroxylase and C17,20 lyase pathways respectively. Steroids 101-109 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 19101629-2 2009 Cytochrome P450C17 (CYP17A1) catalyses the key regulatory step in the formation of the 16-androstene steroids from pregnenolone by the andien-beta synthase reaction or the synthesis of the glucocorticoid and sex steroids via 17alpha-hydroxylase and C17,20 lyase pathways respectively. Steroids 101-109 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-27 17765230-0 2008 A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism. Steroids 48-55 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-27 18645709-2 2008 It is well established that endogenous sex hormones are involved in disease pathogenesis, and polymorphisms in genes encoding enzymes which act in the metabolism of steroid hormones, such as that for cytochrome P450c17alpha enzyme (CYP17), may therefore play a role in fibroid genesis. Steroids 165-181 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 232-237 17975261-7 2007 Such a mixed character of adrenal and gonadal steroid production in human BMCs was supported by the expressions of P450scc, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), P450c21, P450c11, P450c17, 17beta-HSD, and P450arom mRNAs. Steroids 46-53 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 190-197 19040066-1 2008 OBJECTIVE: To investigate the molecular defects of CYP17A1 gene in a pedigree with two 46,XY patients suffering from 17alpha-hydroxylase deficiency (17-OHD) and explore the steroid biosynthetic difference in carriers of 17-OHD before and after adrenocorticotrophic hormone (ACTH) test. Steroids 173-180 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 51-58 18187541-1 2008 Cytochrome P450c17 (P450c17) is the single enzyme that catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities and hence is the crucial decision-making step that determines the class of steroid made in a steroidogenic cell. Steroids 65-72 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 18187541-1 2008 Cytochrome P450c17 (P450c17) is the single enzyme that catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities and hence is the crucial decision-making step that determines the class of steroid made in a steroidogenic cell. Steroids 65-72 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 11-18 18172694-1 2008 Genetic variation in CYP17 is suspected to be related to endometrial cancer risk based on its role in the regulation of steroid and non-steroid hormone biosynthesis. Steroids 120-127 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 21-26 18172694-1 2008 Genetic variation in CYP17 is suspected to be related to endometrial cancer risk based on its role in the regulation of steroid and non-steroid hormone biosynthesis. Steroids 136-151 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 21-26 18493130-6 2008 Qualitative regulation, determining the class of steroid produced, is principally determined by P450c17. Steroids 49-56 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 96-103 16702327-1 2006 Cytochrome P450c17alpha (CYP17) has been associated with alterations in steroid hormone levels and premenopausal breast cancer risk and could modify the association between phytoestrogen intake and breast cancer risk. Steroids 72-87 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-23 17386955-1 2007 Human cytochrome P45017alpha (CYP17), present in mammalian adrenal and gonadal tissues, catalyses both steroid 17-hydroxylation and C17,20 lyase reactions, producing intermediates for the glucocorticoid and androgenic pathways, respectively. Steroids 103-110 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 30-35 17400813-6 2007 Finally, using RT-PCR, we detected expression of genes encoding four key enzymes participating in steroids synthesis (CYP11A1, CYP11B1, CYP17 and CYP21A2) and showed transformation of progesterone into cortisol-immunoreactivity in cultured ARPE-19 cells. Steroids 98-106 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 136-141 16971197-0 2007 CYP17 and COMT gene polymorphisms can influence bone directly, or indirectly through their effects on endogenous sex steroids, in postmenopausal Japanese women. Steroids 117-125 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 16971197-11 2007 Mean percent change in R-BMD showed the difference between COMT homozygote L and non-homozygote L with a larger decrease for the homozygote L. Together, CYP17 and COMT genotypes might have some effect on bone both directly and indirectly through their effects on endogenous sex steroids in postmenopausal Japanese women. Steroids 278-286 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 153-158 16608896-8 2006 RESULTS: In the PORD patients, pregnanediol, pregnanetriolone, and pregnanetriol were obviously elevated, and the urine steroid ratios reflecting CYP17A1 and CYP21A2 activities were decreased throughout the examined ages. Steroids 120-127 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 146-153 17379008-1 2007 Mutations in the CYP17 gene impair steroid biosynthesis in the adrenals and gonads, resulting in 17alpha-hydroxylase/17,20-lyase (P450c17) deficiency, leading to amenorrhea, sexual infantilism, hypokalemia, and hypertension. Steroids 35-42 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 17-22 17379008-1 2007 Mutations in the CYP17 gene impair steroid biosynthesis in the adrenals and gonads, resulting in 17alpha-hydroxylase/17,20-lyase (P450c17) deficiency, leading to amenorrhea, sexual infantilism, hypokalemia, and hypertension. Steroids 35-42 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 130-137 17307805-1 2007 The CYP17 gene is involved in steroid hormone metabolism and has been proposed as a low penetrance gene for breast cancer. Steroids 30-45 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-9 17786626-4 2007 In particular, the genes encoding the steroidogenic acute regulatory protein (StAR) and cytochrome P450 17 alpha hydroxylase/17,20 lyase (CYP17A1) within the steroid hormone biosynthetic pathway are highlighted as ED targets. Steroids 158-173 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 88-136 17786626-4 2007 In particular, the genes encoding the steroidogenic acute regulatory protein (StAR) and cytochrome P450 17 alpha hydroxylase/17,20 lyase (CYP17A1) within the steroid hormone biosynthetic pathway are highlighted as ED targets. Steroids 158-173 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 138-145 16702327-1 2006 Cytochrome P450c17alpha (CYP17) has been associated with alterations in steroid hormone levels and premenopausal breast cancer risk and could modify the association between phytoestrogen intake and breast cancer risk. Steroids 72-87 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 25-30 16103714-9 2005 The ratio of the 17,20 lyase to 17alpha-hydroxylase activity of P450c17 determines the ratio of C21 to C19 steroids produced. Steroids 107-115 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-71 16411751-1 2006 Cytochrome P450c17 (CYP17) catalyzes both the 17alpha-hydroxylase and 17,20-lyase reactions in human steroid biosynthesis. Steroids 101-108 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 16411751-1 2006 Cytochrome P450c17 (CYP17) catalyzes both the 17alpha-hydroxylase and 17,20-lyase reactions in human steroid biosynthesis. Steroids 101-108 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-25 15831526-1 2005 Sex steroid synthesis requires the 17,20 lyase activity of P450c17, which is enhanced by cytochrome b5, acting as an allosteric factor to promote association of P450c17 with its electron donor, P450 oxidoreductase. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 59-66 15831526-1 2005 Sex steroid synthesis requires the 17,20 lyase activity of P450c17, which is enhanced by cytochrome b5, acting as an allosteric factor to promote association of P450c17 with its electron donor, P450 oxidoreductase. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 161-168 15761247-1 2005 CYP17 gene is involved in steroidogenesis and steroid metabolism. Steroids 26-33 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 15823822-2 2005 One of the genes previously implicated in the disease is CYP17; this encodes the enzyme P450c17alpha, which plays a vital role in steroid biosynthesis in the ovary. Steroids 130-137 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 57-62 16306078-1 2006 In the human adrenal cortex, ACTH activates steroid hormone biosynthesis by acutely increasing cholesterol delivery to the mitochondrion and chronically increasing the transcription of steroidogenic genes (including CYP17) via a cAMP-dependent pathway. Steroids 44-59 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 216-221 16030167-9 2005 CONCLUSION: This study suggests that some important steroid hormone-conversion steps are activated (aromatase) and inhibited (second step of the P450c17 and the 3beta-hydroxysteroid dehydrogenase) during the inflammatory attack phase in a TRAPS patient. Steroids 52-67 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 145-152 15878919-1 2005 BACKGROUND: CYP17, which encodes cytochrome P450c17alpha, mediates both steroid 17alpha-hydroxylase and 17,20-lyase activities, and is essential for the production of glucocorticoids and sex steroids. Steroids 191-199 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 12-17 15687493-1 2005 Cytochrome P450c17 catalyzes the 17alpha-hydroxylase activity required for glucocorticoid synthesis and the 17,20 lyase activity required for sex steroid synthesis. Steroids 146-153 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 15730543-3 2005 The steroidogenic enzymes 3beta HSDII (3beta-hydroxysteroid dehydrogenase) and P450c17 (17alpha-hydroxylase/17,20 lyase) are essential for C19 steroid biosynthesis, which is enhanced during adrenarche and in PCOS. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 79-86 15799583-3 2005 The CYP17 gene encodes P450c17alpha, an enzyme involved in the metabolism of steroid hormones. Steroids 77-93 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-9 16280038-4 2005 Furthermore, such analyses would also be relevant to investigation of potential gene-gene interactions between CYP17 and other common variants in genes encoding enzymes that are involved in the synthesis and inactivation of sex steroid hormones, preferably using optimal sets of single nucleotide polymorphisms. Steroids 228-244 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 111-116 15747502-10 2005 Autoantibodies against CYP11A1, CYP17, and/or CYP21 involved in the synthesis of steroid hormones are also detected in patients with adrenal failure, gonadal failure, and/or Addison disease. Steroids 81-97 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 32-37 15220035-1 2004 BACKGROUND: Congenital adrenal hyperplasia with apparent combined P450C17 and P450C21 deficiency is associated with accumulation of steroid metabolites, indicating impaired activity of 17alpha-hydroxylase and 21-hydroxylase. Steroids 132-139 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 66-73 15466495-2 2004 The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis. Steroids 160-175 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-28 15466495-2 2004 The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis. Steroids 160-175 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 30-35 15466495-2 2004 The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis. Steroids 160-175 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 94-118 15562394-1 2004 CYP17 has a dual enzymatic activity that is necessary for steroid hormone biosynthesis. Steroids 58-73 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 15625562-4 2004 TGF-b in turn inhibits steroid hormone output by attenuating both basal and ACTH-dependent expression of CYP17. Steroids 23-38 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 105-110 12954495-3 2003 Two key steps in the sex steroid synthesis are mediated by the enzyme cytochrome p450c17alpha which is encoded in the CYP17 gene. Steroids 25-32 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 118-123 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Steroids 44-52 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Steroids 44-52 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-25 14504283-5 2003 However, mutation E305G lacks 17,20-lyase activity for the conversion of 17alpha-hydroxypregnenolone to DHEA, which is the dominant pathway to C19 steroids catalyzed by human CYP17 (the delta5-steroid pathway). Steroids 147-155 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 175-180 14504283-5 2003 However, mutation E305G lacks 17,20-lyase activity for the conversion of 17alpha-hydroxypregnenolone to DHEA, which is the dominant pathway to C19 steroids catalyzed by human CYP17 (the delta5-steroid pathway). Steroids 147-154 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 175-180 14561815-1 2003 The CYP17 gene encodes the enzyme cytochrome P450c17alpha, which mediates both 17alpha-hydroxylase and 17,20-lyase activity in the steroid biosynthesis pathway. Steroids 131-138 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-9 14561815-1 2003 The CYP17 gene encodes the enzyme cytochrome P450c17alpha, which mediates both 17alpha-hydroxylase and 17,20-lyase activity in the steroid biosynthesis pathway. Steroids 131-138 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 34-57 14522586-7 2003 We conclude that 5alpha-reduced, 3alpha-hydroxy-C(21) steroids are excellent, high-affinity substrates for hCYP17. Steroids 54-62 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 107-113 14522586-8 2003 The brisk metabolism of 5alpha-pregnan-3alpha,17alpha-diol-20-one to androsterone by CYP17 explains how, when 5alpha-reductases are present, the testis can produce C(19) steroids androsterone and androstanediol from 17alpha-hydroxyprogesterone without the intermediacy of androstenedione and testosterone. Steroids 170-178 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 85-90 12915666-1 2003 Cytochrome P450c17 catalyzes both 17alpha-hydroxylation and 17,20-lyase conversion of 21-carbon steroids to 19-carbon precursors of sex steroids. Steroids 96-104 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 15477877-2 2004 To evaluate the effect of the polymorphisms of CYP17 and SRD5A2 on serum steroid hormone levels, the 164 male Japanese cohort were tested for serum hormone levels and the genotype of the polymorphisms of CYP17 (T-C base substitution in the promoter region) and SRD5A2 (V89L). Steroids 73-88 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 47-52 14522586-2 2003 We studied the metabolism of 5alpha-reduced C(21) steroids by human cytochrome P450c17 (hCYP17), the enzyme responsible for conversion of C(21) steroids to C(19) steroids via its 17alpha-hydroxylase and 17,20-lyase activities. Steroids 50-58 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 68-86 14522586-2 2003 We studied the metabolism of 5alpha-reduced C(21) steroids by human cytochrome P450c17 (hCYP17), the enzyme responsible for conversion of C(21) steroids to C(19) steroids via its 17alpha-hydroxylase and 17,20-lyase activities. Steroids 50-58 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 88-94 14522586-2 2003 We studied the metabolism of 5alpha-reduced C(21) steroids by human cytochrome P450c17 (hCYP17), the enzyme responsible for conversion of C(21) steroids to C(19) steroids via its 17alpha-hydroxylase and 17,20-lyase activities. Steroids 144-152 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 68-86 14522586-2 2003 We studied the metabolism of 5alpha-reduced C(21) steroids by human cytochrome P450c17 (hCYP17), the enzyme responsible for conversion of C(21) steroids to C(19) steroids via its 17alpha-hydroxylase and 17,20-lyase activities. Steroids 144-152 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 88-94 12844345-10 2003 In determining activin"s effects on adrenal function, adrenal steroid production was evaluated by incubation of the H295R cells with increasing doses of activin A and inhibin A, resulting in a detectable increase in P450c17 expression. Steroids 62-69 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 216-223 12773039-4 2003 Common chemical features in the steroid and nonsteroid human CYP17 enzyme inhibitors, as deduced by the Catalyst/HipHop program, are one to two hydrogen bond acceptors (HBAs) and three hydrophobic groups. Steroids 32-39 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 61-66 12790800-13 2003 Increasing the CYP17 to HSD3B2 ratio is likely to promote the use of steroid precursors for the production of DHEA(S) and not for cortisol. Steroids 69-76 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 15-20 12631293-3 2003 In this report, we examine at the molecular level whether the enzyme 17 alpha-hydroxylase/17,20-lyase (P450c17), which possesses dual 17 alpha-hydroxylase and 17,20-lyase activities and catalyzes the production of precursors for glucocorticoids and sex steroids, is also able to catalyze the formation of a third class of active steroids, 16-ene steroids (including androstenol). Steroids 253-261 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 103-110 12701064-1 2003 Mutations in the CYP17 gene impair steroid biosynthesis in the adrenals and gonads and often cause 17alpha-hydroxylase/17,20-lyase deficiency, leading to amenorrhea, sexual infantilism, and hypokalemic low aldosterone hypertension. Steroids 35-42 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 17-22 12706306-1 2003 Cytochrome P450c17 deficiency is one of the rare forms of enzyme disorders in steroid biosynthesis, resulting from defects in 17alpha-hydroxylase and 17,20-lyase activities. Steroids 78-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 12631293-3 2003 In this report, we examine at the molecular level whether the enzyme 17 alpha-hydroxylase/17,20-lyase (P450c17), which possesses dual 17 alpha-hydroxylase and 17,20-lyase activities and catalyzes the production of precursors for glucocorticoids and sex steroids, is also able to catalyze the formation of a third class of active steroids, 16-ene steroids (including androstenol). Steroids 329-337 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 103-110 12444089-1 2003 Cytochrome P450c17 catalyzes 17 alpha-hydroxylation needed for cortisol synthesis and 17,20 lyase activity needed to produce sex steroids. Steroids 129-137 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 12573489-3 2003 Hamster P450c17, on the other hand, produces both of these steroids at comparable rates. Steroids 59-67 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 8-15 12464253-2 2003 These two reactions, catalyzed by CYP17, allow for the biosynthesis of the glucocorticoids in the adrenal cortex, as a result of the 17-hydroxylase activity, and for the biosynthesis of androgenic C(19) steroids in the adrenal cortex and gonads as a result of the additional lyase activity. Steroids 203-211 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 34-39 15686129-3 2003 One such gene is CYP17, which encodes the cytochrome P450c17alpha enzyme that mediates both 17alpha-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. Steroids 135-142 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 17-22 12464252-2 2003 Both enzymes hydroxylate progesterone at carbon atoms that lie only 2.6A apart, but CYP17 also metabolizes other steroids and demonstrates additional catalytic activities. Steroids 113-121 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 84-89 12493720-5 2003 The objective of the experiment was to test the hypothesis that exogenous steroid, substrate for P450(c17), would reduce the TCDD effects on E(2) synthesis. Steroids 74-81 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 97-105 15686129-3 2003 One such gene is CYP17, which encodes the cytochrome P450c17alpha enzyme that mediates both 17alpha-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. Steroids 135-142 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 42-65 12573809-7 2002 The ratio of the 17,20 lyase to 17alpha-hydroxylase activity of P450c17 determines the ratio of C21 to C19 steroids produced. Steroids 107-115 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-71 11911969-0 2002 CYP17 genetic polymorphism in endometrial cancer: are only steroids involved? Steroids 59-67 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 12466376-9 2002 The mutations in the steroid-binding domain (F114V and D116V) of P450c17 caused combined, complete (F114V), or partial (D116V) 17alpha-hydroxylase and 17,20-lyase deficiencies, whereas mutations in the redox partner interaction domain (R347C and R347H) displayed less severe 17alpha-hydroxylase deficiency, but complete 17,20-lyase deficiency. Steroids 21-28 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 65-72 12423360-4 2002 Because human and higher primate adrenals secrete steroids, CYP17 has been characterized in the Cape baboon, a species more closely related to humans, in an effort to gain a further understanding of the reactions catalysed by CYP17. Steroids 50-58 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 60-65 12423360-4 2002 Because human and higher primate adrenals secrete steroids, CYP17 has been characterized in the Cape baboon, a species more closely related to humans, in an effort to gain a further understanding of the reactions catalysed by CYP17. Steroids 50-58 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 226-231 12020974-7 2002 Mutant CYP 17 alleles are associated with serum and plasma levels of steroid hormones, use of hormone replacement therapy, and the development of endometrial, prostate, and breast cancer. Steroids 69-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 7-13 11869873-1 2002 The formation of steroids in the H295R human adrenocortical carcinoma cell line was analysed by HPLC or RIA, and based on these data the apparent catalytic activities of CYP11A, CYP17, CYP21 and CYP11B1 in this cell line were calculated. Steroids 17-25 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 178-183 12093119-7 2002 In turn, the inhibition of P450(c17) activity could result in a reduction of androgen production and an increment of C21 steroids. Steroids 121-129 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 27-35 11955795-7 2002 Mutant CYP 17 alleles are associated with serum and plasma levels of steroid hormones, use of hormone replacement therapy, and endometrial, prostate, and breast cancer. Steroids 69-76 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 7-13 11344930-1 2001 P450c17 commands a central role in human steroidogenesis as the qualitative regulator of steroid hormone flux. Steroids 89-104 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 15195127-1 2002 CYP17 gene encodes the enzyme cytochrome p450c17alpha, which mediates two steps in the steroid biosynthesis pathway. Steroids 87-94 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 11463853-1 2001 Cytochrome P450c17 catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities, which are required for the biosynthesis of cortisol and sex steroids. Steroids 145-153 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 11358812-1 2001 Among women, the A2 allele of CYP17 has been associated with elevated levels of endogenous steroid hormones; however, it does not seem to be a strong independent risk factor for breast cancer. Steroids 91-107 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 30-35 11358812-4 2001 In addition, we further examined the relationship between CYP17 genotype and endogenous plasma steroid hormone levels among postmenopausal controls not using hormone replacement therapy (HRT). Steroids 95-110 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 58-63 11880540-2 2002 The CYP17 gene encodes P450c17alpha, an enzyme that is involved in the metabolism of steroid hormones. Steroids 85-101 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-9 11344930-2 2001 Consequently, the study of P450c17 deficiencies in human beings serves to illustrate many aspects of the physiology of steroid biosynthesis and to demonstrate salient features of the genetics and biochemistry of P450c17 itself. Steroids 119-126 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 27-34 11142420-0 2000 Steroid metabolism gene CYP17 polymorphism and the development of breast cancer. Steroids 0-7 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 24-29 10963624-6 2000 A number of molecular epidemiologic studies have been conducted to evaluate associations between polymorphic genes involved in steroid hormone metabolism (i.e., CYP17, COMT, CYP1A1, CYP19, GST, and MnSOD) that may account for a proportion of enzymatic variability, and results are discussed in this review. Steroids 127-142 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 161-166 10760835-1 2000 The CYP17 gene encodes the cytochrome P450c17alpha enzyme, which functions at 2 different points in the steroid biosynthesis pathway, and is considered a candidate susceptibility gene for endocrine-related tumors. Steroids 104-111 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-9 11036113-1 2000 BACKGROUND: The cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5" promoter region of the CYP17 gene. Steroids 64-71 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 27-34 11036113-1 2000 BACKGROUND: The cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5" promoter region of the CYP17 gene. Steroids 64-71 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 236-241 11036113-1 2000 BACKGROUND: The cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5" promoter region of the CYP17 gene. Steroids 117-132 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 27-34 11036113-1 2000 BACKGROUND: The cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5" promoter region of the CYP17 gene. Steroids 117-132 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 236-241 11036113-2 2000 Because steroid hormone exposure is known to influence breast cancer risk, we conducted a population-based, case-control-family study to assess the relationship between the CYP17 promoter polymorphism and early-onset breast cancer. Steroids 8-23 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 173-178 11059764-1 2000 The CYP17 gene (CYP17) codes for the cytochrome P450c17alpha enzyme, which mediates two key steps in the sex steroid synthesis. Steroids 109-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-9 11059764-1 2000 The CYP17 gene (CYP17) codes for the cytochrome P450c17alpha enzyme, which mediates two key steps in the sex steroid synthesis. Steroids 109-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 16-21 10897051-1 2000 CYP17 encodes the enzyme cytochrome P-450c17 alpha, which mediates both 17 alpha-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. Steroids 116-123 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 10897051-1 2000 CYP17 encodes the enzyme cytochrome P-450c17 alpha, which mediates both 17 alpha-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. Steroids 116-123 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 25-50 9796641-1 1998 A nested case-control study was conducted to determine whether a genetic polymorphism in the CYP17 gene, which encodes for an enzyme that mediates steroid hormone metabolism, was associated with an increased risk of breast cancer. Steroids 147-162 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 93-98 11117668-1 2000 Cytochrome P450c17 is a multifunctional enzyme that converts C21 steroids to the C19 sex steroid precursor DHEA. Steroids 65-73 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 11117668-1 2000 Cytochrome P450c17 is a multifunctional enzyme that converts C21 steroids to the C19 sex steroid precursor DHEA. Steroids 65-72 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 10407219-11 1999 The earlier increase in Delta(5)-steroids in girls may suggest a sharper rise in ovarian cytochrome P450c17 activity along the Delta(5)-steroid pathway, while the failure of estradiol to increase in response to leuprolide acetate in early pubertal males suggests a late maturation of aromatase activity. Steroids 33-40 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 100-107 10070957-1 1999 The A2 allele of CYP17 has been associated with polycystic ovarian syndrome, elevated levels of certain steroid hormones in premenopausal women, and increased breast cancer risk. Steroids 104-120 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 17-22 10070957-3 1999 We also evaluated associations between this CYP17 genotype and plasma steroid hormone levels among postmenopausal controls not using hormone replacement to assess the biological significance of this genetic variant. Steroids 70-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 44-49 9892022-1 1999 Cytochrome P450c17 catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities and hence is a key enzyme in the production of human glucocorticoids and sex steroids. Steroids 161-169 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 9888582-2 1998 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. Steroids 240-248 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 19-26 9768686-5 1998 The enzyme 3betaHSD competes for substrate with CYP17 and effectively removes steroid precursor from the pathway leading to DHEA. Steroids 78-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 48-53 9888582-2 1998 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. Steroids 240-248 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 152-159 8699135-17 1996 The influence of these important intraovarian factors on the expression of P450c17, a pivotal enzyme in thecal cell production of C19 steroids, could impact greatly on the follicular milieu of a normal developing follicle as well as in pathophysiological disorders such as polycystic ovarian syndrome. Steroids 134-142 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 75-82 9755461-5 1998 The studies of enzymatic regulation of P450c17 suggest that cytochrome b5 (b5), a heme protein, may switch the reaction of P450c17 by enhancing the 17, 20-lyase activity to increase the level of plasma C19 steroids. Steroids 206-214 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 39-46 9755461-5 1998 The studies of enzymatic regulation of P450c17 suggest that cytochrome b5 (b5), a heme protein, may switch the reaction of P450c17 by enhancing the 17, 20-lyase activity to increase the level of plasma C19 steroids. Steroids 206-214 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 123-130 9755461-7 1998 Therefore, this enhancement by b5 on the lyase activity of P450c17 may be essential to normal sexual differentiation in humans and also important in control of an optimal balance between sex steroid hormones and glucocorticoids. Steroids 191-207 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 59-66 9452426-1 1998 In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both the 17alpha-hydroxylation of 21-carbon steroids and the 17,20-lyase activity that cleaves the C17-C20 bond to produce C19 sex steroids. Steroids 23-30 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 41-48 9452426-1 1998 In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both the 17alpha-hydroxylation of 21-carbon steroids and the 17,20-lyase activity that cleaves the C17-C20 bond to produce C19 sex steroids. Steroids 129-137 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 41-48 9452426-4 1998 Yeast expressing only P450c17 have 17alpha-hydroxylase and trace 17,20-lyase activities toward both Delta4 and Delta5 steroids. Steroids 118-126 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 9888535-7 1998 This paper describes the procedure in detail, using P450c17 as an example, and highlights the opportunities that computational chemistry offers for the study of sex steroid biosynthesis. Steroids 165-172 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-59 9703423-10 1998 This 1-bp deletion produces a frameshift in translation and introduces a premature stop codon (TAG) proximal to the highly conserved heme iron-binding cysteine at codon 442 in microsomal cytochrome P450 steroid 17alpha-hydroxylase (P450c17). Steroids 203-210 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 232-239 9648052-4 1998 Immunohistochemical staining with the use of antibody directed against human cytochrome P450c17 (CYP17) revealed that in polycystic as well as in normal ovaries, steroid 17 alpha-hydroxylase is localised mainly in the thecal cells of atretic follicles and in the interstitial cells of the stroma. Steroids 162-169 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 77-95 9648052-4 1998 Immunohistochemical staining with the use of antibody directed against human cytochrome P450c17 (CYP17) revealed that in polycystic as well as in normal ovaries, steroid 17 alpha-hydroxylase is localised mainly in the thecal cells of atretic follicles and in the interstitial cells of the stroma. Steroids 162-169 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 97-102 9029728-1 1997 P450c17 is a single microsomal enzyme that catalyzes two distinct steroid biosynthetic activities: 17 alpha-hydroxylase and 17,20 lyase. Steroids 66-73 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 8675607-1 1996 Evidence is provided that mRNA for ACTH (MC-2) receptor and mRNAs for three obligatory enzymes of steroid synthesis including cytochromes P450scc, P450c17 and P450c21 are expressed in normal and pathologic human skin. Steroids 98-105 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 147-154 7811386-1 1994 In mammalian and fish species, P450c17 mediates both 17 alpha-hydroxylase and 17,20-lyase activities in the synthesis of steroid hormones. Steroids 121-137 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 31-38 8597483-3 1995 The cells were characterized with regard to responsiveness to a variety of agents as measured by steroid secretion and induction of 17 alpha-hydroxylase cytochrome P450 (P450c17) expression, a key enzyme in C19-steroid production. Steroids 211-218 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 170-177 7479852-1 1995 Microsomal cytochrome P450c17 catalyzes both steroid 17 alpha-hydroxylase activity and scission of the C17-C20 steroid bond (17,20-lyase) on the same active site. Steroids 45-52 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 11-29 7588323-9 1995 Furthermore, the effects of K+ on steroid secretion and 17 alpha-hydroxylase activity were reproduced by the voltage-sensitive Ca2+ channel activator BAYK 8644, and increases in P450c17 mRNA in response to K+ were reversed by the Ca2+ channel antagonist, nifedipine. Steroids 34-41 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 178-185 7811386-2 1994 Previous results have shown that among the adrenal steroid hydroxylase enzymes involved in adrenal C19 steroid and glucocorticoid synthesis, regulation of cytochrome P450c17 is of primary importance because it is localized at the key branch between glucocorticoid and C19 steroid synthesis. Steroids 51-58 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 166-173 8323292-4 1993 The apparent Ks values for these steroids are comparable to those obtained under the same conditions with wild type P450c17. Steroids 33-41 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 116-123 7849715-0 1994 Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17. Steroids 93-100 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 117-122 8106620-8 1994 In APD-I, antibodies recognized as frequently P450c17 and P450scc, specific for all steroid-producing cells as the adrenal specific enzyme P450c21. Steroids 84-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 46-53 8396576-11 1993 A key enzyme in the production of C19 steroids is P450c17. Steroids 38-46 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 50-57 1605399-2 1992 Cytochrome P450XVII (steroid-17 alpha-monooxygenase/steroid-17,20-lyase), one key enzyme in steroid hormone biosynthesis, responds to external human choriogonadotropin stimulation with an oxygen-dependent and substrate flux-dependent inactivation and decomposition, and increased substrate availability decreases the efficiency of androgen formation in favour of abortive intermediate leakage. Steroids 92-107 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 21-51 8432024-4 1993 Our studies have emphasized the cholesterol side-chain cleavage enzyme P450scc, which catalyzes the first and rate-limiting step in steroidogenesis, and P450c17, which determines what class of steroids is synthesized. Steroids 193-201 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 153-160 8323171-4 1993 These results suggest that this pattern of steroid secretion results from abnormal regulation (dysregulation) of these activities, possibly involving the enzyme cytochrome P450c17. Steroids 43-50 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 172-179 34538754-1 2021 Polycystic ovary syndrome (PCOS) is a multifactorial reproductive and endocrine disease, believed to be caused by aberrant steroid biosynthesis pathways involving cytochrome P450, 17alpha-hydroxylase (CYP17A1). Steroids 123-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 201-208 1714904-1 1991 Steroid 17 alpha-hydroxylase deficiency is caused by defects in cytochrome P450c17, the single enzyme that has 17-alpha hydroxylase and 17,20-lyase activities. Steroids 0-7 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 75-82 34563259-5 2021 Studies with ovarian theca cells taken from PCOS women have demonstrated increased androgen production due to augmented ovarian steroidogenesis attributed to mainly altered expression of critical enzymes (Cytochrome P450 enzymes: CYP17, CYP21, CYP19, CYP11A) in the steroid hormone biosynthesis pathway. Steroids 266-273 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 230-235 32530640-1 2020 As an important member of cytochrome P450 (CYP) enzymes, CYP17A1 is a dual-function monooxygenase with a critical role in the synthesis of many human steroid hormones, rendering it as an attractive therapeutic target. Steroids 150-157 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 57-64 35085884-9 2022 For steroidogenesis, alpha/beta-TBCO, PBEB, and EHTBB all upregulated genes encoding for steroid synthesis enzymes, including 17betaHSD, CYP11B1 and CYP17. Steroids 89-96 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 149-154 35132941-5 2022 To investigate the activation pathway of synthesized N-formyl pyrazoline substituted steroid derivatives, a molecular docking study was performed on human cytochrome P450-(CYP17A1: PDB ID 5IRQ) with the help of the free AutoDock Vina. Steroids 85-92 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 172-179 35087285-2 2022 This study aimed to investigate the association between polymorphism in seven steroid hormone metabolism genes (STAR, HSD3B1, HSD3B2, CYP17A1, CYP21A2, CYP11B1, and CYP11B2) and HAPE susceptibility among Han Chinese. Steroids 78-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 134-141 33844306-5 2021 Molecular docking experiments confirmed that AST can form stable binding to several key nodes (SRD5A2, STS, AKR1C2, HSD11B1, and CYP17A1) in steroid hormone biosynthesis. Steroids 141-148 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 129-136 35287432-1 2022 The multifunctional cytochrome P450 17A1 (CYP17A1) plays a crucial role in human steroid hormone synthesis (UniProtKB P05093). Steroids 81-88 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-40 35287432-1 2022 The multifunctional cytochrome P450 17A1 (CYP17A1) plays a crucial role in human steroid hormone synthesis (UniProtKB P05093). Steroids 81-88 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 42-49 3500022-1 1987 P450c17 is a single cytochrome P450 enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities in the biosynthesis of steroid hormones. Steroids 129-145 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 3025870-1 1987 P450c17 is the single enzyme mediating both 17 alpha-hydroxylase (steroid 17 alpha-monooxygenase, EC 1.14.99.9) and 17,20 lyase activities in the synthesis of steroid hormones. Steroids 66-73 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 33753170-0 2021 Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis. Steroids 99-106 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 34-54 32456493-3 2021 It is believed that the excess androgens are produced due to abnormality in steroid biosynthesis pathway wherein cytochrome P450, 17alpha-hydroxylase (CYP17) plays an imperative role. Steroids 76-83 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 151-156 33436964-8 2021 Among the steroidogenic enzymes, CYP17A1 mediates steroid 17alpha-hydroxylation and 17,20-lyase reaction, necessary for testosterone production. Steroids 10-17 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 33-40 32516371-9 2020 CONCLUSIONS: The elevated production of hybrid steroids by posture-unresponsive APAs may relate to their ZF-like tumor cell composition, resulting in expression of CYP17A1 (in addition to somatic gene mutation-driven CYP11B2 expression), thereby allowing production of cortisol which acts as the substrate for CYP11B2-generated hybrid steroids. Steroids 47-55 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 164-171 32660148-2 2020 CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated in prostate cancer. Steroids 89-97 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 32007561-1 2020 Cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17A1) plays a pivotal role in the regulation of adrenal and gonadal steroid hormone biosynthesis. Steroids 120-127 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 49-56 32007561-3 2020 Increased CYP17A1 activity in endocrine disorders and diseases are associated with elevated C21 and C19 steroids which include 17alpha-hydroxyprogesterone and androgens, as well as C11-oxy C21 and C11-oxy C19 steroids. Steroids 104-112 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 10-17 31509771-2 2019 In pigs and humans, CYP17A1 also catalyses the delta-16-synthase reaction to produce the 16-androstene steroid 5,16-androstadien-3beta-ol (16A), which is then further metabolised to the sex pheromone androstenone. Steroids 103-110 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-27 33780934-1 2020 CONTEXT: Steroid 17alpha-hydroxylase/17,20-lyase deficiency (17OHD) is characterized by decreased sex steroids and cortisol, and excessive mineralocorticoid action. Steroids 102-110 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 9-48 31691616-2 2020 Most defects in CYP17A1 impair both enzymatic activities and cause a combined 17alpha-hydroxylase/17,20-lyase deficiency, which impairs hormone production (cortisol and sex steroids), sexual development, and puberty. Steroids 173-181 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 16-23 31509771-5 2019 This included residues in the steroid binding pocket of CYP17A1 and residues on the surface of CYP17A1 and CYB5A that are involved in binding of CYP17A1 to CYB5A. Steroids 30-37 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 56-63 31207124-0 2019 Impact of hormonal contraceptives on urinary steroid profile in relation to serum hormone changes and CYP17A1 polymorphism. Steroids 45-52 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 102-109 31169883-9 2019 Five of these loci relate to genes directly involved in steroid metabolism, that is, CYP21A1, CYP11B1, CYP17A1, STS, and HSD17B12, almost completing the set of steroidogenic enzymes with genetic associations. Steroids 56-63 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 103-110 31356544-1 2019 BACKGROUND: Cytochrome P450 17A1 (CYP17A1) catalyzes the formation and metabolism of steroid hormones and is required for cortisol and androgens. Steroids 85-92 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 12-32 31150682-7 2019 The levels of steroids and expression of relevant steroidogenic enzymes (e.g., CYP17A1, HSD3B1, HSD3B2, CYP11B1 and AKR1C4) we significantly higher in the hFK at GW11-12 compared to GW9. Steroids 14-22 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 79-86 31330226-6 2019 Clotrimazole inhibited steroid production in a dose-dependent manner with IC50 values for CYP17A1 and CYP19A1 in the range 0.017-0.184 muM. Steroids 23-30 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 90-97 31356544-1 2019 BACKGROUND: Cytochrome P450 17A1 (CYP17A1) catalyzes the formation and metabolism of steroid hormones and is required for cortisol and androgens. Steroids 85-92 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 34-41 30066910-9 2018 Enrichment analysis indicated that cytochrome P450 family 17 subfamily A member 1 (CYP17A1) was associated with "positive regulation of steroid hormone biosynthetic processes". Steroids 136-151 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 35-81 31072872-0 2019 Conformational selection dominates binding of steroids to human cytochrome P450 17A1. Steroids 46-54 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-84 31031706-3 2019 We focused on cytochrome P450 17alpha-hydroxylase (CYP17A1) which catalyses the production of dehydroepiandrosterone (DHEA), in the androgen biosynthesis pathway to elucidate effects on sex steroids in vitro. Steroids 190-198 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 51-58 31039398-7 2019 In LNCaP cells expressing CYP17A1, 11alphaOHP4 and 11betaOHP4 were metabolised with negligible substrate, 4%, remaining after 48 h, while the steroid substrate 11beta,17alpha-dihydroxyprogesterone (21dF) was metabolised to C11-keto C19 steroids yielding 11-ketotestosterone. Steroids 142-149 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 26-33 31039398-7 2019 In LNCaP cells expressing CYP17A1, 11alphaOHP4 and 11betaOHP4 were metabolised with negligible substrate, 4%, remaining after 48 h, while the steroid substrate 11beta,17alpha-dihydroxyprogesterone (21dF) was metabolised to C11-keto C19 steroids yielding 11-ketotestosterone. Steroids 236-244 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 26-33 31039398-8 2019 Despite the fact that 11alphaOHP4 is not metabolised by 11betaHSD2, it is a substrate for SRD5A and CYP17A1, yielding C11alpha-hydroxy C19 steroids as well as the C11alpha-hydroxy derivative of 21dF-the latter associated with clinical conditions characterised by androgen excess. Steroids 139-147 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 100-107 30825506-5 2019 Data highlighted the role of 11betaHSD2 and cytochrome P450 17A1 in the contribution of C11-oxy C21 steroids to the C11-oxy C19 steroid pool in the C11-oxy backdoor pathway. Steroids 100-108 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 44-64 30825506-5 2019 Data highlighted the role of 11betaHSD2 and cytochrome P450 17A1 in the contribution of C11-oxy C21 steroids to the C11-oxy C19 steroid pool in the C11-oxy backdoor pathway. Steroids 100-107 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 44-64 30066910-9 2018 Enrichment analysis indicated that cytochrome P450 family 17 subfamily A member 1 (CYP17A1) was associated with "positive regulation of steroid hormone biosynthetic processes". Steroids 136-151 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 83-90 29338791-1 2018 BACKGROUND: The genome-wide association study has founded hypertension-related single nucleotide polymorphism (SNP) rs11191548 near CYP17A1 encoding a key enzyme involved in steroid metabolism, but the molecular mechanisms are not understood and the associations of the SNP with hypertension-related traits are not fully described, especially in children. Steroids 174-181 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 132-139 29888793-1 2018 Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two-step reaction process: allylic hydroxylation and carbo-carbon bond scission. Steroids 77-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 29888793-1 2018 Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two-step reaction process: allylic hydroxylation and carbo-carbon bond scission. Steroids 77-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 29880207-0 2018 Corrigendum to "Comparison of [17(20)E]-21-Norpregnene oxazolinyl and benzoxazolyl derivatives as inhibitors of CYP17A1 activity and prostate carcinoma cells growth" [Steroids 129 (2018) 24-34]. Steroids 167-175 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 112-119 29942286-1 2018 Background: Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) gene encodes a key enzyme in the synthesis and metabolism of steroid hormones and has been associated with various factors, such as hypertension, insulin resistance, and polycystic ovary syndrome. Steroids 130-146 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 12-58 29942286-1 2018 Background: Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) gene encodes a key enzyme in the synthesis and metabolism of steroid hormones and has been associated with various factors, such as hypertension, insulin resistance, and polycystic ovary syndrome. Steroids 130-146 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 60-67 29710837-1 2018 The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. Steroids 31-38 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-11 27566228-1 2017 Cytochrome P450 17A1 (CYP17A1) operates at the core of human steroidogenesis, directing precursors into mineralocorticoids, glucocorticoids, or sex steroids. Steroids 148-156 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 28992603-4 2017 Moreover, two SNPs (CYP17 -34 T:C (MSP AI) and CYP19 T:C (Trp:Arg)) of cytochrome P450, which is involved in steroid metabolism pathways, were analysed between the groups. Steroids 109-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-25 28609197-1 2017 17alpha-Hydroxylase deficiency is an uncommon type of congenital adrenal hyperplasia (CAH) caused by mutations in the CYP17A1 gene encoding both 17alpha-hydroxylase and 17,20-lyase, essential for sex steroids production. Steroids 200-208 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 118-125 28890368-1 2017 CYP17A1-independent intratumoral steroid hormone synthesis is regarded as one possible explanation for resistance to treatment with the CYP17-inhibitor Abiraterone (Abi). Steroids 33-48 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 28890368-6 2017 Co-administration of Abi lead to detectable concentrations of the Abi metabolite Delta4-Abi (D4A), known to inhibit enzymes other than CYP17A1 in steroid metabolism. Steroids 146-153 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 135-142 28786422-0 2017 Prostate cancer: The influence of steroid metabolism on CYP17A1 inhibitor activity. Steroids 34-41 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 56-63 28373265-2 2017 The steroid abiraterone, the active form of the only CYP17A1 inhibitor approved by the Food and Drug Administration, binds the catalytic heme iron, nonselectively impeding both reactions and ultimately causing undesirable corticosteroid imbalance. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 53-60 28272372-3 2017 In this review article, we describe common polymorphisms at three steroidogenic loci (CYP11B2, CYP11B1 and CYP17A1) that alter gene transcription efficiency and levels of key steroids, including aldosterone. Steroids 175-183 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 107-114 28389510-4 2017 Levels correlated positively with steroids upstream of CYP17A (pregnenolone, progesterone), and inversely with steroids downstream of CYP17A (DHEA, AED, testosterone). Steroids 34-42 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 55-60 28684414-1 2017 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens. Steroids 58-65 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-32 20301592-6 1993 DIAGNOSIS/TESTING: The diagnosis of PORD can be established by urinary steroid profiling using gas chromatography / mass spectrometry (GC/MS), which documents combined impairment of 17alpha-hydroxylase (CYP17A1) and 21-hydroxylase (CYP21A2) enzymatic activity located at key branch points of cortisol, aldosterone, and sex steroid synthesis. Steroids 71-78 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 203-210 27566228-1 2017 Cytochrome P450 17A1 (CYP17A1) operates at the core of human steroidogenesis, directing precursors into mineralocorticoids, glucocorticoids, or sex steroids. Steroids 148-156 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 27083183-1 2016 Cytochrome P450 17A1 (CYP17A1) is the requisite enzyme for synthesis of sex steroids, including estrogens and androgens. Steroids 76-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 26862015-1 2017 Steroid 17-hydroxylase 17,20-lyase (cytochrome P450c17, P450 17A1, CYP17A1) catalyzes two major reactions: steroid 17-hydroxylation followed by the 17,20-lyase reactions. Steroids 107-114 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 36-54 26862015-1 2017 Steroid 17-hydroxylase 17,20-lyase (cytochrome P450c17, P450 17A1, CYP17A1) catalyzes two major reactions: steroid 17-hydroxylation followed by the 17,20-lyase reactions. Steroids 107-114 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 67-74 27217499-10 2016 CONCLUSIONS: The pattern of steroid secretion caused by acetaminophen can be explained by inhibition of CYP17A1 enzyme activity. Steroids 28-35 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 104-111 27083183-1 2016 Cytochrome P450 17A1 (CYP17A1) is the requisite enzyme for synthesis of sex steroids, including estrogens and androgens. Steroids 76-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 26297028-4 2016 CYP17A1 activity was assessed by 2 ratios of urinary steroid metabolites: one estimating the combined 17alpha-hydroxylase/17,20-lyase activity (ratio 1) and the other predominantly 17alpha-hydroxylase activity (ratio 2). Steroids 53-60 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 26704533-5 2016 The steroid levels (47 steroids and steroid polar conjugates) and their ratios in AD female patients indicated increased CYP11A1 activity, weakened activity of the CYP17A1C17,20 lyase metabolic step and attenuated sulfotransferase SULT2A1 activity at higher activity of the CYP17A1 17-hydroxylase step. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 164-171 26902494-0 2016 Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus. Steroids 57-64 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 28-35 26704533-5 2016 The steroid levels (47 steroids and steroid polar conjugates) and their ratios in AD female patients indicated increased CYP11A1 activity, weakened activity of the CYP17A1C17,20 lyase metabolic step and attenuated sulfotransferase SULT2A1 activity at higher activity of the CYP17A1 17-hydroxylase step. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 274-281 25936248-0 2015 Genetic Basis of the Relationship Between Reproduction and Longevity: A Study on Common Variants of Three Genes in Steroid Hormone Metabolism--CYP17, HSD17B1, and COMT. Steroids 115-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 143-148 26025587-1 2015 Cytochrome P450 (CYP) 17A1 is a dual-function monooxygenase with a critical role in the synthesis of many human steroid hormones. Steroids 112-128 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-26 26781511-8 2016 Clustering of the concentration-dependent chemical-mediated steroid hormone effects grouped chemical samples into 5 distinct profiles generally representing putative mechanisms of action, including CYP17A1 and HSD3B inhibition. Steroids 60-75 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 198-205 26432395-1 2016 Biosynthesis of steroid hormones in vertebrates involves three cytochrome P450 hydroxylases, CYP11A1, CYP17A1 and CYP19A1, which catalyze sequential steps in steroidogenesis. Steroids 16-23 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 102-109 26682016-1 2015 Cytochrome P450 17A1 (CYP17A1) is associated in the steroid hormone biosynthesis in human. Steroids 52-67 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 26682016-1 2015 Cytochrome P450 17A1 (CYP17A1) is associated in the steroid hormone biosynthesis in human. Steroids 52-67 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 26682016-2 2015 As cell proliferation of prostate cancer in response to androgen steroid, an inhibition of CYP17A1 becomes an alternative approach to inhibit biosynthesis of androgen and support treatment of prostate cancer. Steroids 65-72 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 91-98 25936248-2 2015 The variation of three genes in steroid hormone metabolism--CYP17 (rs743572), HSD17B1 (rs 605059), and COMT (rs4680)--was examined to elucidate the genetic basis of the relationship between fertility and life span. Steroids 32-47 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 60-65 26051784-2 2015 A new class of steroids is being synthesized for its ability to prevent intratumoral androgen production by inhibiting the activity of CYP17 hydroxylase enzyme. Steroids 15-23 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 135-140 25970467-3 2015 We showed that human adrenocortical H295R cells grown under starvation conditions acquire a hyperandrogenic steroid profile with changes in steroid metabolizing enzymes HSD3B2 and CYP17A1 essential for androgen production. Steroids 140-147 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 180-187 25650406-4 2015 CYP17A1 deficiency was suspected at 2 months on the basis of steroid analysis performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Steroids 61-68 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 25448501-4 2015 A functionally significant variant within the promoter region of CYP17 has been linked to variation in steroid production, and some evidence suggests that this polymorphism could alter transcription of CYP17 in an insulin-dependent manner. Steroids 103-110 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 65-70 25448501-4 2015 A functionally significant variant within the promoter region of CYP17 has been linked to variation in steroid production, and some evidence suggests that this polymorphism could alter transcription of CYP17 in an insulin-dependent manner. Steroids 103-110 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 202-207 26263970-1 2015 Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. Steroids 73-89 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 26263970-1 2015 Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. Steroids 73-89 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 25482340-1 2015 The steroid hydroxylation and carbon-carbon bond cleavage activities of cytochrome P450 17A1 (CYP17A1) are responsible for the production of glucocorticoids and androgens, respectively. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 72-92 25482340-1 2015 The steroid hydroxylation and carbon-carbon bond cleavage activities of cytochrome P450 17A1 (CYP17A1) are responsible for the production of glucocorticoids and androgens, respectively. Steroids 4-11 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 94-101 25224484-1 2015 A single enzyme, microsomal P450c17, catalyzes the 17alpha-hydroxylase activity needed to make cortisol and the subsequent 17,20 lyase activity needed to produce the 19-carbon precursors of sex steroids. Steroids 194-202 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 28-35 26161337-1 2015 17alpha-hydroxylase and 17,20-lyase are enzymes encoded by the CYP17A1 gene and are required for the synthesis of sex steroids and cortisol. Steroids 118-126 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 63-70 25678418-8 2015 CYP17A1, CYP19A1 and CYP27A1 catalyzed steroid synthesis, including hydroxylation at 17alpha, 19 and 27 positions, respectively. Steroids 39-46 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 26701948-1 2015 The CYP17A1 gene encodes the enzyme P450c17, which mediates both 17alpha-hydroxylase and 17,20-lyase activities and is essential for production of cortisol and sex steroids. Steroids 164-172 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-11 26701948-1 2015 The CYP17A1 gene encodes the enzyme P450c17, which mediates both 17alpha-hydroxylase and 17,20-lyase activities and is essential for production of cortisol and sex steroids. Steroids 164-172 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 36-43