Title : Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.

Pub. Date : 2017 Aug 11

PMID : 28684414






1 Functional Relationships(s)
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1 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens. Steroids cytochrome P450 family 17 subfamily A member 1 Homo sapiens