| 1 |
35366770 | Insights into Interactions of Human Cytochrome P450 17A1: Review. | 2022 Apr 1 |
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| 2 |
33157220 | Modified bile acids and androstanes-Novel promising inhibitors of human cytochrome P450 17A1. | 2021 Jan |
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| 3 |
33656879 | Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5. | 2021 Mar 17 |
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| 4 |
34662099 | Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1. | 2021 Nov 2 |
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| 5 |
34867807 | Effects of Midazolam on the Development of Adult Leydig Cells From Stem Cells In Vitro. | 2021 |
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| 6 |
32215889 | Clinical, Molecular, Functional, and Structural Characterization of CYP17A1 Mutations in Brazilian Patients with 17-Hydroxylase Deficiency. | 2020 Mar |
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| 7 |
33102564 | Knockdown of CYP19A1 in Buffalo Follicular Granulosa Cells Results in Increased Progesterone Secretion and Promotes Cell Proliferation. | 2020 |
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| 8 |
30468857 | SPR-Based study of affinity of cytochrome P450s / redox partners interactions modulated by steroidal substrates. | 2019 Mar |
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| 9 |
31426637 | 180 Day Repeated-Dose Toxicity Study on Forchlorfenuron in Sprague-Dawley Rats and Its Effects on the Production of Steroid Hormones. | 2019 Sep 11 |
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| 10 |
29758981 | Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone. | 2018 Jun 13 |
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| 11 |
29888793 | Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step. | 2018 Jul |
2 |
| 12 |
29981252 | Protein Engineering of the Progesterone Hydroxylating P450-Monooxygenase CYP17A1 Alters Its Regioselectivity. | 2018 Sep 17 |
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| 13 |
30229581 | Functional Identification of Compound Heterozygous Mutations in the CYP17A1 Gene Resulting in Combined 17α-Hydroxylase/17,20-Lyase Deficiency. | 2018 Sep |
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| 14 |
28387522 | Mechanism of Cytochrome P450 17A1-Catalyzed Hydroxylase and Lyase Reactions. | 2017 May 22 |
2 |
| 15 |
28684414 | Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. | 2017 Aug 11 |
2 |
| 16 |
24593890 | [Congenital adrenal hyperplasia due to lack of 17α-hydroxylase: a report of a new mutation in the gene CYP17A1]. | 2015 Jan |
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| 17 |
25320358 | Abiraterone treatment in castration-resistant prostate cancer selects for progesterone responsive mutant androgen receptors. | 2015 Mar 15 |
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| 18 |
25929975 | The CYP17 MspA1 Polymorphism and the Gender Dysphoria. | 2015 Jun |
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| 19 |
25386927 | Epoxidation activities of human cytochromes P450c17 and P450c21. | 2014 Dec 9 |
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| 20 |
22155568 | Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells. | 2012 Mar 5 |
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| 21 |
22419734 | Genetic polymorphism CYP17 rs2486758 and metabolic risk factors predict daily salivary 17β-estradiol concentration in healthy premenopausal Norwegian women. The EBBA-I study. | 2012 May |
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| 22 |
22873692 | Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates. | 2012 Sep 11 |
2 |
| 23 |
20619364 | At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17. | 2011 Jan |
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| 24 |
21094146 | Steroid synthesis by primary human keratinocytes; implications for skin disease. | 2011 Jan 7 |
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| 25 |
21095220 | 16α-hydroxyprogesterone: origin, biosynthesis and receptor interaction. | 2011 Apr 10 |
2 |
| 26 |
20043997 | A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase. | 2010 Apr |
3 |
| 27 |
19211174 | Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls. | 2009 Jul |
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| 28 |
19267349 | A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer. | 2009 Jun 15 |
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| 29 |
19495700 | Placental and fetal steroidogenesis. | 2009 |
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| 30 |
17786540 | SMAD3 inhibits SF-1-dependent activation of the CYP17 promoter in H295R cells. | 2008 Jan |
2 |
| 31 |
19169487 | Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a homozygous 25 BP duplication (NT 4157-4181) at exon 5 in the CYP17 resulting in a premature stop codon predicted by molecular modeling. | 2008 Nov |
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| 32 |
17386955 | Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris. | 2007 May 10 |
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| 33 |
17400813 | Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium. | 2007 Apr |
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| 34 |
16595705 | Direct electrochemistry of human, bovine and porcine cytochrome P450c17. | 2006 Apr |
1 |
| 35 |
14715826 | Two intronic mutations cause 17-hydroxylase deficiency by disrupting splice acceptor sites: direct demonstration of aberrant splicing and absent enzyme activity by expression of the entire CYP17 gene in HEK-293 cells. | 2004 Jan |
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| 36 |
12464252 | The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21. | 2003 Jan 1 |
3 |
| 37 |
12464253 | Ovine steroid 17alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme. | 2003 Jan 1 |
1 |
| 38 |
12915666 | The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway. | 2003 Aug |
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| 39 |
12949806 | CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China. | 2003 Nov 1 |
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| 40 |
14504283 | CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. | 2003 Dec 5 |
2 |
| 41 |
14671162 | P450c17 deficiency in Brazilian patients: biochemical diagnosis through progesterone levels confirmed by CYP17 genotyping. | 2003 Dec |
3 |
| 42 |
12423360 | Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17). | 2002 Nov |
3 |
| 43 |
10999829 | Bone morphogenetic protein inhibits ovarian androgen production. | 2000 Sep |
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| 44 |
9485002 | Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations. | 1998 Feb 15 |
2 |
| 45 |
9888582 | The molecular basis of isolated 17,20 lyase deficiency. | 1998 Aug-Nov |
2 |
| 46 |
7588392 | Expression of human P450c17 as an export protein in Saccharomyces cerevisiae. | 1995 Feb-May |
2 |
| 47 |
7588393 | The effect of cytochrome b5 on progesterone metabolism in the ovine adrenal. | 1995 Feb-May |
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| 48 |
7893148 | The role of cytochrome b5 in the biosynthesis of androgens by human P450c17. | 1995 Mar 10 |
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| 49 |
8015556 | Modeling and mutagenesis of the active site of human P450c17. | 1994 Mar |
2 |
| 50 |
8323292 | Expression in Escherichia coli of functional cytochrome P450c17 lacking its hydrophobic amino-terminal signal anchor. | 1993 Jul |
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