Title : Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.

Pub. Date : 2018 Jun 13

PMID : 29758981






1 Functional Relationships(s)
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1 The multifunctional enzyme, cytochrome P450 (CYP17A1), plays a crucial role in the production of androgens, catalyzing two key reactions on pregnenolone (PREG) and progesterone (PROG), the first being a 17-hydroxylation to generate 17-OH PREG and 17-OH PROG, with roughly equal efficiencies. Progesterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens