Pub. Date : 2021 Nov 2
PMID : 34662099
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An important branch point in human androgen production is catalyzed by cytochrome P450 CYP17A1 and involves an initial Compound I-mediated hydroxylation at the 17-position of either progesterone (PROG) or pregnenolone (PREG) to form 17-hydroxy derivatives, 17OH-PROG and 17OH-PREG, with approximately similar efficiencies. | Progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | An important branch point in human androgen production is catalyzed by cytochrome P450 CYP17A1 and involves an initial Compound I-mediated hydroxylation at the 17-position of either progesterone (PROG) or pregnenolone (PREG) to form 17-hydroxy derivatives, 17OH-PROG and 17OH-PREG, with approximately similar efficiencies. | Progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | For example, the replacement of the glutamic acid side with a glycine chain at position 305 in the CYP17A1 structure causes a clinically relevant steroidopathy; E305G CYP17A1 displays a dramatic decrease in the production of dehydroepiandrosterone from pregnenolone but surprisingly increases the activity of the enzyme toward the formation of androstenedione from progesterone. | Progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | For example, the replacement of the glutamic acid side with a glycine chain at position 305 in the CYP17A1 structure causes a clinically relevant steroidopathy; E305G CYP17A1 displays a dramatic decrease in the production of dehydroepiandrosterone from pregnenolone but surprisingly increases the activity of the enzyme toward the formation of androstenedione from progesterone. | Progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |