Title : Modeling and mutagenesis of the active site of human P450c17.

Pub. Date : 1994 Mar

PMID : 8015556






2 Functional Relationships(s)
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1 By positioning the progesterone substrate into each model, we identified five residues that appeared crucial for determining whether progesterone would undergo 17 alpha-hydroxylation (by P450c17) or 21-hydroxylation (by P450c21). Progesterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 By positioning the progesterone substrate into each model, we identified five residues that appeared crucial for determining whether progesterone would undergo 17 alpha-hydroxylation (by P450c17) or 21-hydroxylation (by P450c21). Progesterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens