PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35366770-5 2022 This P450c17 cytochrome gene is a critical steroidogenesis regulator which performs two distinct activities: 17 alpha-hydroxylase activity (converting pregnenolone to 17-hydroxypregnenolone and progesterone to 17-hydroxyprogesterone, these precursors are further processed to provide glucocorticoids and sex hormones) and 17, 20-lyase activity (which converts 17-hydroxypregnenolone to DHEA). Progesterone 194-206 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 5-12 8015556-4 1994 By positioning the progesterone substrate into each model, we identified five residues that appeared crucial for determining whether progesterone would undergo 17 alpha-hydroxylation (by P450c17) or 21-hydroxylation (by P450c21). Progesterone 19-31 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 187-194 8015556-4 1994 By positioning the progesterone substrate into each model, we identified five residues that appeared crucial for determining whether progesterone would undergo 17 alpha-hydroxylation (by P450c17) or 21-hydroxylation (by P450c21). Progesterone 133-145 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 187-194 8323292-3 1993 When intact E. coli cells were used for analysis, the truncated P450c17 showed the typical cytochrome P450 CO-difference spectrum and type I substrate binding spectra for pregnenolone, 17 alpha-hydroxypregnenolone, progesterone, and 17 alpha-hydroxyprogesterone. Progesterone 215-227 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-71 7893148-4 1995 Other activities catalyzed by P450c17 include 17 alpha-hydroxylation of progesterone and pregnenolone and are much less influenced by cytochrome b5. Progesterone 72-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 30-37 7588392-1 1995 Cytochrome P450c17 (P450c17), together with cytochrome P450c21 (P450c21), plays an important role in progesterone metabolism in the mammalian adrenal cortex. Progesterone 101-113 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 7588392-1 1995 Cytochrome P450c17 (P450c17), together with cytochrome P450c21 (P450c21), plays an important role in progesterone metabolism in the mammalian adrenal cortex. Progesterone 101-113 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 11-18 7588393-6 1995 The P450c17-activity in sheep adrenal microsomes is inhibited by the addition of purified cyt b5 while anti-cyt b5 IgG stimulates the 17 alpha-hydroxylation of progesterone. Progesterone 160-172 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-11 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. Progesterone 232-244 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-50 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. Progesterone 232-244 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-47 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. Progesterone 232-244 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 121-125 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. Progesterone 232-244 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 121-125 8325965-1 1993 Progesterone and pregnenolone are metabolized to 17 alpha-hydroxysteroids by a cytochrome P450-dependent 17 alpha-hydroxylase (P450c17). Progesterone 0-12 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 127-134 8325965-3 1993 We investigated the metabolism of progesterone by monkey kidney tumor (COS 1) cells transfected with a plasmid vector containing the cDNA encoding the complete amino acid sequence for human cytochrome P450c17. Progesterone 34-46 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 190-208 8325965-10 1993 Antibodies raised against porcine cytochrome P450c17 inhibited the 17 alpha- and 16 alpha-hydroxylation of progesterone to the same extent when using fetal adrenal microsomes, whereas no inhibition of 21-hydroxylation of progesterone was observed. Progesterone 107-119 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-52 8325965-10 1993 Antibodies raised against porcine cytochrome P450c17 inhibited the 17 alpha- and 16 alpha-hydroxylation of progesterone to the same extent when using fetal adrenal microsomes, whereas no inhibition of 21-hydroxylation of progesterone was observed. Progesterone 221-233 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-52 34867807-9 2021 The uneven changes in steroidogenic pathway proteins, especially reductions in CYP17A1 at high midazolam levels, also result in an accumulation of progesterone. Progesterone 147-159 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 79-86 34662099-3 2021 An important branch point in human androgen production is catalyzed by cytochrome P450 CYP17A1 and involves an initial Compound I-mediated hydroxylation at the 17-position of either progesterone (PROG) or pregnenolone (PREG) to form 17-hydroxy derivatives, 17OH-PROG and 17OH-PREG, with approximately similar efficiencies. Progesterone 182-194 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 87-94 34662099-3 2021 An important branch point in human androgen production is catalyzed by cytochrome P450 CYP17A1 and involves an initial Compound I-mediated hydroxylation at the 17-position of either progesterone (PROG) or pregnenolone (PREG) to form 17-hydroxy derivatives, 17OH-PROG and 17OH-PREG, with approximately similar efficiencies. Progesterone 196-200 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 87-94 34662099-7 2021 For example, the replacement of the glutamic acid side with a glycine chain at position 305 in the CYP17A1 structure causes a clinically relevant steroidopathy; E305G CYP17A1 displays a dramatic decrease in the production of dehydroepiandrosterone from pregnenolone but surprisingly increases the activity of the enzyme toward the formation of androstenedione from progesterone. Progesterone 365-377 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 99-106 34662099-7 2021 For example, the replacement of the glutamic acid side with a glycine chain at position 305 in the CYP17A1 structure causes a clinically relevant steroidopathy; E305G CYP17A1 displays a dramatic decrease in the production of dehydroepiandrosterone from pregnenolone but surprisingly increases the activity of the enzyme toward the formation of androstenedione from progesterone. Progesterone 365-377 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 167-174 33157220-5 2021 Results presented here showed that these steroidal compounds are able to decrease rate of hydroxylation of essential CYP17A1 substrate - progesterone, while some compounds completely inhibited enzyme activity. Progesterone 137-149 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 117-124 33656879-1 2021 CYP17A1 is an essential human steroidogenic enzyme, which catalyzes two sequential reactions leading to the formation of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone. Progesterone 142-154 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 32215889-11 2020 CYP17A1 activity of p.G478S was 13 and 58% against progesterone and 17-hydroxypregnenolone, respectively. Progesterone 51-63 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 33102564-6 2020 Moreover, CYP19A1 knockdown increased (P < 0.05) the concentrations of progesterone secretion (P4) in BFGCs through increasing the mRNA expression levels of three steroidogenic genes (HSD17B1, HSD17B7, and CYP17A1). Progesterone 71-83 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 206-213 29981252-0 2018 Protein Engineering of the Progesterone Hydroxylating P450-Monooxygenase CYP17A1 Alters Its Regioselectivity. Progesterone 27-39 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 73-80 31426637-6 2019 In addition, it was found that FCF inhibited the proliferation of granulosa cells (GCs) and H295R cells, as well as downregulated the expression of CYP17A1 and CYP19A1 in estradiol and progesterone production, resulting in decreased steroidogenesis in GCs and H295R cells. Progesterone 185-197 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 148-155 30468857-4 2019 The equilibrium dissociation constant (Kd) value of the CYB5A/CYP17A1 complex decreased by 5 times in the presence of progesterone (P4), which was due to a 10 times increase in the association rate constant (kon). Progesterone 118-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 62-69 25320358-3 2015 Therefore, we sought to determine if CYP17A1 inhibitor treatment selects for progesterone-activated mutant ARs. Progesterone 77-89 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 37-44 29758981-1 2018 The multifunctional enzyme, cytochrome P450 (CYP17A1), plays a crucial role in the production of androgens, catalyzing two key reactions on pregnenolone (PREG) and progesterone (PROG), the first being a 17-hydroxylation to generate 17-OH PREG and 17-OH PROG, with roughly equal efficiencies. Progesterone 164-176 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-52 28387522-1 2017 Cytochrome P450 17A1 (CYP17A1) catalyzes C17 hydroxylation of pregnenolone and progesterone and the subsequent C17-C20 bond cleavage (lyase reaction) to form androgen precursors. Progesterone 79-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 28387522-1 2017 Cytochrome P450 17A1 (CYP17A1) catalyzes C17 hydroxylation of pregnenolone and progesterone and the subsequent C17-C20 bond cleavage (lyase reaction) to form androgen precursors. Progesterone 79-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 25929975-1 2015 INTRODUCTION: The A2 allele of the CYP17 MspA1 polymorphism has been linked to higher levels of serum testosterone, progesterone, and estradiol. Progesterone 116-128 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 35-40 30229581-6 2018 And the activities of 17alpha-hydroxylase and 17,20-lyase of CYP17A1 were evaluated by measuring the conversion of progesterone to 17alpha-hydroxyprogesterone and of 17alpha-hydroxypregnenolone to dehydroepiandrosterone, respectively. Progesterone 115-127 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 61-68 29888793-1 2018 Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two-step reaction process: allylic hydroxylation and carbo-carbon bond scission. Progesterone 113-125 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 29888793-1 2018 Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two-step reaction process: allylic hydroxylation and carbo-carbon bond scission. Progesterone 113-125 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 28684414-0 2017 Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. Progesterone 51-63 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 103-123 28684414-1 2017 Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens. Progesterone 140-152 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-32 24593890-1 2015 P450c17 enzyme catalyses two different reactions: the 17alpha-hydroxylation of progesterone and pregnenolone, and segmenting the carbon 17-20 binding from the 17,20lyase producing adrenal androgens. Progesterone 79-91 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 22873692-1 2012 The steroid hydroxylases CYP17A1 (P450c17, 17-hydroxylase/17,20-lyase) and CYP21A2 (P450c21, 21-hydroxylase) catalyze progesterone hydroxylation at one or more sites within a 2 A radius. Progesterone 118-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 25-32 25386927-4 2014 We reasoned that human P450c17 (steroid 17-hydroxylase/17,20-lyase, CYP17A1), which 17- and 16alpha-hydroxylates progesterone, might catalyze the formation of the 16alpha,17-epoxide from 16,17-dehydroprogesterone (pregna-4,16-diene-3,20-dione). Progesterone 113-125 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 23-66 25386927-4 2014 We reasoned that human P450c17 (steroid 17-hydroxylase/17,20-lyase, CYP17A1), which 17- and 16alpha-hydroxylates progesterone, might catalyze the formation of the 16alpha,17-epoxide from 16,17-dehydroprogesterone (pregna-4,16-diene-3,20-dione). Progesterone 113-125 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 68-75 22873692-1 2012 The steroid hydroxylases CYP17A1 (P450c17, 17-hydroxylase/17,20-lyase) and CYP21A2 (P450c21, 21-hydroxylase) catalyze progesterone hydroxylation at one or more sites within a 2 A radius. Progesterone 118-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 34-41 22155568-0 2012 Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells. Progesterone 69-81 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 129-134 22419734-3 2012 OBJECTIVE: The aim of this study was to determine whether common polymorphisms in CYP17, in combination with metabolic risk factors (individually or clustered), alter salivary concentrations of free biologically active 17beta-estradiol and progesterone among healthy premenopausal Norwegian women. Progesterone 240-252 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 82-87 21095220-1 2011 The metabolism of progesterone (PROG) by cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17alpha-hydroxyprogesterone (17-OHPROG) and 16alpha-hydroxyprogesterone (16-OHPROG) in humans. Progesterone 18-30 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 41-88 21095220-1 2011 The metabolism of progesterone (PROG) by cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17alpha-hydroxyprogesterone (17-OHPROG) and 16alpha-hydroxyprogesterone (16-OHPROG) in humans. Progesterone 18-30 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 90-97 17786540-1 2008 Cytochrome P450c17, encoded by the CYP17 gene, is a component of 17alpha-hydroxylase/17,20 lyase which catalyses 17alpha-hydroxylation of pregnenolone or progesterone, required for glucocorticosteroid and androgen synthesis. Progesterone 154-166 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 20043997-1 2010 In adrenal steroidogenesis, CYP17 catalyses the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17,20-lyase reaction, yielding adrenal androgens. Progesterone 90-102 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 28-33 20043997-3 2010 CYP17 has also been shown to exhibit 16alpha-hydroxylase activity towards progesterone in some species, with only human and chimp CYP17 catalysing the biosynthesis of substantial amounts of 16-OHprogesterone. Progesterone 74-86 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 20043997-6 2010 Wt human CYP17 converted approximately 30% progesterone to 16-OHprogesterone while the Ala105Leu mutant converted negligible amounts to 16-OHprogesterone ( approximately 9%), comparable to wt CYP17 of the other three species when expressed in COS-1 cells. Progesterone 43-55 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 9-14 19267349-5 2009 CYP17A1 activity assays were conducted in human serum (and positive control human liver and kidney microsomes) using progesterone as a precursor and an LC-MS endpoint. Progesterone 117-129 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 21094146-6 2011 Trilostane (a 3betaHSD1 inhibitor) and ketoconazole (a CYP17A1 inhibitor) blocked the metabolism of both pregnenolone and progesterone. Progesterone 122-134 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 55-62 20619364-4 2011 CYP17 catalyzes the 17alpha-hydroxylation reaction of delta4-C21 steroids (progesterone derivatives) and delta5-C21 steroids (pregnenolone derivatives) as well as the 17,20-lyase reaction producing C19-steroids, a key branch point in steroid hormone biosynthesis. Progesterone 75-87 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 19211174-5 2009 Therefore we decided to synthesize non-steroidal compounds mimicking the natural CYP17 substrates pregnenolone and progesterone. Progesterone 115-127 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 81-86 19495700-3 2009 This chapter describes methods for the measurement of the expression and catalytic activity of three key cytochrome P450 (CYP) enzymes involved in the production of progesterone and estrogens, aromatase (CYP19), steroid 17-hydroxylase/17,20-lyase (CYP17), and cholesterol side-chain cleavage (CYP11A). Progesterone 165-177 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 248-253 19169487-3 2008 In the present study, we described a novel CYP17 mutation in two Brazilian sisters with primary amenorrhea, 46,XY karyotype, high basal levels of progesterone (3.4-4.9 ng/mL) and hypokalemic hypertension born to consanguineous parents. Progesterone 146-158 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-48 17786540-1 2008 Cytochrome P450c17, encoded by the CYP17 gene, is a component of 17alpha-hydroxylase/17,20 lyase which catalyses 17alpha-hydroxylation of pregnenolone or progesterone, required for glucocorticosteroid and androgen synthesis. Progesterone 154-166 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 35-40 16595705-7 2006 The effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone. Progesterone 110-122 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 56-63 17400813-6 2007 Finally, using RT-PCR, we detected expression of genes encoding four key enzymes participating in steroids synthesis (CYP11A1, CYP11B1, CYP17 and CYP21A2) and showed transformation of progesterone into cortisol-immunoreactivity in cultured ARPE-19 cells. Progesterone 184-196 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 136-141 17386955-8 2007 The expressed enzyme catalysed the conversion of progesterone to 17-hydroxyprogesterone as well as 16-hydroxyprogesterone, a product unique to human and chimpanzee CYP17. Progesterone 49-61 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 164-169 12949806-2 2003 The enzyme P450c17alpha, encoded by the CYP17 gene, catalyzes the conversion of progesterone and pregnenolone into precursors of potent androgens. Progesterone 80-92 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 40-45 14715826-5 2004 The mRNA derived from the wild-type CYP17 gene was correctly spliced and translated into active enzyme, as shown by the correct sequence in the RT-PCR products and by the 17-hydroxylation of progesterone. Progesterone 191-203 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 36-41 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Progesterone 70-82 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 14504283-1 2003 Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. Progesterone 70-82 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 20-25 14671162-0 2003 P450c17 deficiency in Brazilian patients: biochemical diagnosis through progesterone levels confirmed by CYP17 genotyping. Progesterone 72-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 14671162-8 2003 Therefore, we elucidated the genotype of 11 individuals with p450c17 deficiency and concluded that basal progesterone measurement is a useful marker of p450c17 deficiency and that its use should reduce the misdiagnosis of this deficiency in patients presenting with male pseudohermaphroditism, primary or secondary amenorrhea, and mineralocorticoid excess syndrome. Progesterone 105-117 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 61-68 14671162-8 2003 Therefore, we elucidated the genotype of 11 individuals with p450c17 deficiency and concluded that basal progesterone measurement is a useful marker of p450c17 deficiency and that its use should reduce the misdiagnosis of this deficiency in patients presenting with male pseudohermaphroditism, primary or secondary amenorrhea, and mineralocorticoid excess syndrome. Progesterone 105-117 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 152-159 12915666-2 2003 P450c17 can mediate testosterone biosynthesis via the conversion of pregnenolone to dehydroepiandrosterone (the delta(5) pathway) or via conversion of progesterone to androstenedione (the delta(4) pathway). Progesterone 151-163 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 12464252-0 2003 The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21. Progesterone 18-30 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 98-105 12464253-4 2003 Ovine CYP17 expressed in HEK 293 cells converts progesterone to 17-hydroxyprogesterone and pregnenolone to dehydroepiandrosterone via 17-hydroxypregnenolone. Progesterone 48-60 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 6-11 12464252-2 2003 Both enzymes hydroxylate progesterone at carbon atoms that lie only 2.6A apart, but CYP17 also metabolizes other steroids and demonstrates additional catalytic activities. Progesterone 25-37 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 84-89 12464252-5 2003 The ent-progesterone forms a type I difference spectrum with CYP17, but molecular dynamics simulations suggest different binding orientations for progesterone and its enantiomer. Progesterone 8-20 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 61-66 12423360-1 2002 Human cytochrome P450 17alpha-hydroxylase (CYP17) catalyses not only the 17alpha-hydroxlation of pregnenolone and progesterone and the C17,20-side chain cleavage (lyase) of 17alpha-hydroxypregnenolone, necessary for the biosynthesis of C21-glucocorticoids and C19-androgens, but also catalyses the 16alpha-hydroxylation of progesterone. Progesterone 114-126 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-48 12423360-6 2002 Baboon CYP17 has apparent Km and V values for pregnenolone and progesterone of 0.9 micro m and 0.4 nmol.h-1.mg protein-1 and 6.5 micro m and 3.9 nmol.h-1.mg protein-1, respectively. Progesterone 63-75 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 7-12 12423360-7 2002 Baboon CYP17 had a significantly higher activity for progesterone hydroxylation relative to pregnenolone. Progesterone 53-65 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 7-12 10999829-21 2000 In conclusion, BMP-4 inhibits HOTT cell expression of CYP17, leading to an alteration of steroidogenic pathway resulting in reduced androstenedione accumulation and increased progesterone production. Progesterone 175-187 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 54-59 9888582-1 1998 Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. Progesterone 94-106 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 6-13 9888582-1 1998 Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. Progesterone 94-106 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 144-151 9485002-0 1998 Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations. Progesterone 88-100 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-23 9485002-0 1998 Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations. Progesterone 88-100 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 30-35