| 1 |
35085884 | Integrated assessment of endocrine disrupting potential of four novel brominated flame retardants. | 2022 Mar 1 |
1 |
| 2 |
35087285 | Association Between the Polymorphism of Steroid Hormone Metabolism Genes and High-Altitude Pulmonary Edema in the Chinese Han Population. | 2022 |
1 |
| 3 |
35132941 | Synthesis, molecular docking, molecular dynamics and evaluation of Drug-Likeness properties of the fused N-Formyl pyrazoline substituted new dehydroepiandrosterone derivatives. | 2022 Feb 8 |
1 |
| 4 |
35287432 | Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1. | 2022 Apr 5 |
2 |
| 5 |
32456493 | CYP17 gene polymorphic sequence variation is associated with hyperandrogenism in Kashmiri women with polycystic ovarian syndrome. | 2021 Mar |
1 |
| 6 |
33436964 | Gene expression and functional abnormalities in XX/Sry Leydig cells. | 2021 Jan 12 |
1 |
| 7 |
33753170 | Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis. | 2021 Jan-Jun |
1 |
| 8 |
33844306 | Analysis of astaxanthin molecular targets based on network pharmacological strategies. | 2021 May |
1 |
| 9 |
34538754 | The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis. | 2021 Nov |
1 |
| 10 |
34563259 | The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis. | 2021 Sep 26 |
1 |
| 11 |
31691616 | A rare enzymatic defect, true isolated 17,20-lyase deficiency leading to endocrine disorders and infertility: case report. | 2020 Apr |
1 |
| 12 |
32007561 | CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. | 2020 May |
2 |
| 13 |
32516371 | Biochemical, Histopathological, and Genetic Characterization of Posture-Responsive and Unresponsive APAs. | 2020 Sep 1 |
1 |
| 14 |
32530640 | Comparative Dynamics and Functional Mechanisms of the CYP17A1 Tunnels Regulated by Ligand Binding. | 2020 Jul 27 |
1 |
| 15 |
32660148 | Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents. | 2020 Jul 9 |
1 |
| 16 |
33780934 | Genotypic Sex and Severity of the Disease Determine the Time of Clinical Presentation in Steroid 17α-Hydroxylase/17,20-Lyase Deficiency. | 2020 |
1 |
| 17 |
30825506 | The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis. | 2019 May |
2 |
| 18 |
31031706 | The Effect of Soy Isoflavones on Steroid Metabolism. | 2019 |
1 |
| 19 |
31039398 | 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro. | 2019 Jul |
3 |
| 20 |
31072872 | Conformational selection dominates binding of steroids to human cytochrome P450 17A1. | 2019 Jun 28 |
1 |
| 21 |
31150682 | Steroidogenic potential of human fetal kidney at early gestational age. | 2019 Sep |
1 |
| 22 |
31169883 | Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. | 2019 Nov 1 |
1 |
| 23 |
31207124 | Impact of hormonal contraceptives on urinary steroid profile in relation to serum hormone changes and CYP17A1 polymorphism. | 2019 Sep |
1 |
| 24 |
31330226 | The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax. | 2019 Sep 1 |
1 |
| 25 |
31356544 | CYP17A1 Polymorphisms Are Linked to the Risk of Coronary Heart Disease in a Case-Control Study. | 2019 Aug |
2 |
| 26 |
31509771 | Effect of mutations in porcine CYB5A and CYP17A1 on the metabolism of pregnenolone. | 2019 Dec |
2 |
| 27 |
29338791 | Associations of the hypertension-related single nucleotide polymorphism rs11191548 with high-density lipoprotein cholesterol and leptin in Chinese children. | 2018 Jan 16 |
1 |
| 28 |
29710837 | Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency. | 2018 Apr 29 |
1 |
| 29 |
29880207 | Corrigendum to "Comparison of [17(20)E]-21-Norpregnene oxazolinyl and benzoxazolyl derivatives as inhibitors of CYP17A1 activity and prostate carcinoma cells growth" [Steroids 129 (2018) 24-34]. | 2018 Aug |
1 |
| 30 |
29888793 | Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step. | 2018 Jul |
2 |
| 31 |
29942286 | A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese. | 2018 |
2 |
| 32 |
30066910 | A random forest classifier predicts recurrence risk in patients with ovarian cancer. | 2018 Sep |
2 |
| 33 |
26862015 | Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic. | 2017 Jan |
2 |
| 34 |
27566228 | Structural insights into the function of steroidogenic cytochrome P450 17A1. | 2017 Feb 5 |
2 |
| 35 |
28272372 | ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure. | 2017 Mar 7 |
1 |
| 36 |
28373265 | Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. | 2017 Jun |
1 |
| 37 |
28389510 | Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer. | 2017 Aug 15 |
1 |
| 38 |
28609197 | The Glu331del mutation in the CYP17A1 gene causes atypical congenital adrenal hyperplasia in a 46,XX female. | 2017 Dec |
1 |
| 39 |
28684414 | Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. | 2017 Aug 11 |
1 |
| 40 |
28786422 | Prostate cancer: The influence of steroid metabolism on CYP17A1 inhibitor activity. | 2017 Oct |
1 |
| 41 |
28890368 | CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. | 2017 Nov |
2 |
| 42 |
28992603 | Sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering. | 2017 Dec |
1 |
| 43 |
26297028 | CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study. | 2016 Apr |
1 |
| 44 |
26432395 | Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution. | 2016 Jan |
1 |
| 45 |
26704533 | Preliminary evidence of altered steroidogenesis in women with Alzheimer's disease: Have the patients "OLDER" adrenal zona reticularis? | 2016 Apr |
2 |
| 46 |
26781511 | High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells. | 2016 Apr |
1 |
| 47 |
26902494 | Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus. | 2016 Apr |
1 |
| 48 |
27083183 | The CYP17A1 inhibitor abiraterone exhibits estrogen receptor agonist activity in breast cancer. | 2016 May |
2 |
| 49 |
27217499 | Acetaminophen Increases Aldosterone Secretion While Suppressing Cortisol and Androgens: A Possible Link to Increased Risk of Hypertension. | 2016 Oct |
1 |
| 50 |
24832628 | 3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging. | 2015 |
1 |