Guanosine Triphosphate

coagulation factor II, thrombin ; Homo sapiens







42 Article(s)
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1 29735342 Dabigatran reduces endothelial permeability through inhibition of thrombin-induced cytoskeleton reorganization. 2018 Apr 25 2
2 28509344 cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway. 2017 Aug 1
3 18495810 Rho-family GTPases modulate Ca(2+) -dependent ATP release from astrocytes. 2008 Jul 2
4 16299551 Signaling mechanism of thrombin-induced gingival fibroblast-populated collagen gel contraction. 2006 Jan 1
5 15640525 Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells. 2005 Mar 18 2
6 15130921 Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells. 2004 Jul 1
7 15613030 Activation of the small GTPase Rap2B in agonist-stimulated human platelets. 2004 Dec 1
8 12515716 IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. 2003 Apr 15 4
9 11799111 Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. 2002 Apr 5 1
10 12045195 Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration. 2002 Aug 9 2
11 11397694 Small GTP-binding protein Ral modulates regulated exocytosis of von Willebrand factor by endothelial cells. 2001 Jun 1
12 10455022 Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution. 1999 Sep 1 1
13 10572250 Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments. 1999 Dec 15 1
14 9741823 Thrombin signal transduction of the fibrinolytic system in human adult venous endothelium in vitro. 1998 Jul 1
15 9238049 Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. 1997 Aug 5 1
16 8780738 Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin receptor agonist peptide. 1996 Aug 23 2
17 7529999 Possible involvement of protein kinase C and low molecular weight GTP-binding proteins in thrombin-induced histamine secretion in human platelets. 1995 Jan 17 1
18 7619088 Effect of propranolol on platelet signal transduction. 1995 Jul 1 1
19 7630424 Analysis of receptor-G protein interactions in permeabilized cells. 1995 Apr 1
20 8042983 Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. 1994 Jul 15 2
21 8280749 Effect of cAMP on the association of small GTP-binding proteins with the cytoskeleton of human platelets. 1994 Jan 5 1
22 8356066 Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. 1993 Aug 15 1
23 8396137 A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells. 1993 Sep 15 1
24 8400019 Receptor-mediated signalling pathways acting through hydrolysis of membrane phospholipids in cardiomyocytes. 1993 Sep 1
25 1333596 Exogenous GTP increases cyclic GMP and inhibits thrombin-induced aggregation of washed human platelets: comparison with ATP, adenosine and guanosine. 1992 Oct 4
26 1530576 Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). 1992 Sep 1 2
27 2112463 Guanine nucleotides and Ca2(+)-dependent lysosomal secretion in electropermeabilised human platelets. 1990 May 20 1
28 2494171 Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. Signaling mechanisms distinguished by sensitivity to pertussis toxin and phorbol esters. 1989 Mar 15 2
29 2831052 Effects of guanosine 5'-[gamma-thio]triphosphate and thrombin on the phosphoinositide metabolism of electropermeabilized human platelets. 1988 Feb 1 2
30 2833222 Stimulation of high-affinity GTPase by trypsin and trypsin-like proteinases in membranes of human platelets. 1988 Feb 1 2
31 3134260 Guanine nucleotides inhibit agonist-stimulated arachidonic acid release in both intact and saponin-permeabilized human platelets. 1988 Jul 18 2
32 2822018 Stimulation of polyphosphoinositide hydrolysis by thrombin in membranes from human fibroblasts. 1987 Jul 1 3
33 3106084 Stimulus-response coupling in a cell-free platelet membrane system. GTP-dependent release of Ca2+ by thrombin, and inhibition by pertussis toxin and a monoclonal antibody that blocks calcium release by IP3. 1987 Apr 6 2
34 3107563 GDP beta S enhances the activation of phospholipase C caused by thrombin in human platelets: evidence for involvement of an inhibitory GTP-binding protein. 1987 May 14 5
35 3112131 Guanine nucleotides stimulate arachidonic acid release by phospholipase A2 in saponin-permeabilized human platelets. 1987 Apr 1
36 3015130 GTP and cytosol stimulate phosphoinositide hydrolysis in isolated platelet membranes. 1986 Jun 13 1
37 3021450 Effects of guanine nucleotides on the properties of 5-hydroxytryptamine secretion from electropermeabilised human platelets. 1986 Oct 1 2
38 3023367 Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi. 1986 Dec 25 1
39 3026330 Evidence for two GTPases activated by thrombin in membranes of human platelets. 1986 Aug 1 6
40 3032044 Thrombin-cellular interactions. 1986 1
41 6098673 Receptor-induced diacylglycerol formation in permeabilized platelets; possible role for a GTP-binding protein. 1984 1
42 6437813 Ni-mediated inhibition of human platelet adenylate cyclase by thrombin. 1984 Dec 3 5