Title : GDP beta S enhances the activation of phospholipase C caused by thrombin in human platelets: evidence for involvement of an inhibitory GTP-binding protein.

Pub. Date : 1987 May 14

PMID : 3107563






5 Functional Relationships(s)
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Protein Name
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1 Ca2+ has opposite effects on the formation of [3H]inositol phosphates induced by thrombin or GTP gamma S. While the action of GTP gamma S on the formation of [3H]inositol phosphates is inhibited by Ca2+, action of thrombin is stimulated by Ca2+. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
2 Ca2+ has opposite effects on the formation of [3H]inositol phosphates induced by thrombin or GTP gamma S. While the action of GTP gamma S on the formation of [3H]inositol phosphates is inhibited by Ca2+, action of thrombin is stimulated by Ca2+. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
3 Guanosine 5"-O-(2-thiodiphosphate) (GDP beta S), which inhibits the function of GTP-binding proteins, also inhibits the effect of GTP gamma S on phospholipase C stimulation but, surprisingly, increases the effect of thrombin. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
4 Guanosine 5"-O-(2-thiodiphosphate) (GDP beta S), which inhibits the function of GTP-binding proteins, also inhibits the effect of GTP gamma S on phospholipase C stimulation but, surprisingly, increases the effect of thrombin. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
5 However, the effect of thrombin may be modulated by the action of an inhibitory GTP-binding protein. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens