Title : IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization.

Pub. Date : 2003 Apr 15

PMID : 12515716






4 Functional Relationships(s)
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1 IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
2 Platelet activation by alpha-thrombin, but not saturating concentrations of fibrillar collagen or adenosine 5"-diphosphate, uniquely assemble an IQGAP2/arp2/3-actin cytoplasmic complex, an association regulated by guanosine triphosphate rac1 ([GTP]rac1) but not by [GTP]cdc42. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
3 Platelet activation by alpha-thrombin, but not saturating concentrations of fibrillar collagen or adenosine 5"-diphosphate, uniquely assemble an IQGAP2/arp2/3-actin cytoplasmic complex, an association regulated by guanosine triphosphate rac1 ([GTP]rac1) but not by [GTP]cdc42. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
4 Platelet activation by alpha-thrombin, but not saturating concentrations of fibrillar collagen or adenosine 5"-diphosphate, uniquely assemble an IQGAP2/arp2/3-actin cytoplasmic complex, an association regulated by guanosine triphosphate rac1 ([GTP]rac1) but not by [GTP]cdc42. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens