Title : Exogenous GTP increases cyclic GMP and inhibits thrombin-induced aggregation of washed human platelets: comparison with ATP, adenosine and guanosine.

Pub. Date : 1992 Oct

PMID : 1333596






4 Functional Relationships(s)
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1 Exogenous GTP increases cyclic GMP and inhibits thrombin-induced aggregation of washed human platelets: comparison with ATP, adenosine and guanosine. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
2 GTP (10 microM-1 mM) dose-dependently inhibited thrombin-induced aggregation and serotonin secretion. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
3 The rank order of inhibition of thrombin-induced aggregation of washed human platelets was adenosine > GTP > ATP > guanosine. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
4 In conclusion, exogenous GTP inhibits thrombin-induced aggregation and serotonin secretion of washed human platelets by increasing cyclic GMP. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens