Title : Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells.

Pub. Date : 2005 Mar 18

PMID : 15640525






2 Functional Relationships(s)
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1 Thrombin also rapidly stimulated GTP loading of RhoA, which was blocked by acute pretreatment with either atorvastatin or GGTI-286. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens
2 We provide the evidence that, in thrombin-stimulated ECs, the unprocessed form of RhoA is rapidly geranylgeranylated to become the mature form, which then is converted into GTP-bound active RhoA. Guanosine Triphosphate coagulation factor II, thrombin Homo sapiens