Pub. Date : 1986 Aug 1
PMID : 3026330
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thrombin inhibits adenylate cyclase and stimulates GTP hydrolysis by high-affinity GTPase(s) in membranes of human platelets at almost identical concentrations. | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 2 | However, stimulation of GTP hydrolysis caused by adrenaline (alpha 2-adrenoceptor agonist) and by thrombin at maximally effective concentrations was partially additive, whereas with regard to adenylate cyclase inhibition no additive response was observed. | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 3 | Additionally, the thiol reagent N-ethylmalemide (NEM) at rather low concentrations abolished thrombin- and adrenaline-induced stimulation of GTP hydrolysis was decreased by only 30-40% by treatment of platelet membranes with even high concentrations of NEM. | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 4 | The data suggest that thrombin interaction with its receptor sites in platelet membranes leads to stimulation of two GTP-hydrolysing enzymes. | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 5 | The other GTP-hydrolysing enzyme activated by thrombin may represent a guanine nucleotide-binding protein apparently involved in the coupling of thrombin receptors to the phosphoinositide phosphodiesterase. | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 6 | The other GTP-hydrolysing enzyme activated by thrombin may represent a guanine nucleotide-binding protein apparently involved in the coupling of thrombin receptors to the phosphoinositide phosphodiesterase. | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |