Simvastatin

tumor necrosis factor ; Homo sapiens







108 Article(s)
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51 19932975 Effect of simvastatin on endothelial cell apoptosis mediated by Fas and TNF-alpha. 2010 Jan 3
52 20097734 Alterations in molecular chaperones and eIF2alpha during lung endothelial cell apoptosis. 2010 Apr 1
53 20676966 On the combined effect of statins and lycopene on cytokine production by human peripheral blood cells. 2010 Sep 1
54 20863785 Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. 2010 Dec 15 3
55 18830905 Changes in disease activity, cytokine production, and proliferation of peripheral blood mononuclear cells in patients with rheumatoid arthritis after simvastatin treatment. 2009 Jan-Feb 1
56 19008785 Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol. 2009 Aug 1
57 19205663 The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. 2009 Jul 1
58 19324974 Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. 2009 Jun 15 1
59 19410078 Simvastatin as a novel strategy to alleviate periapical lesions. 2009 May 2
60 19481207 Shear stress preconditioning modulates endothelial susceptibility to circulating TNF-alpha and monocytic cell recruitment in a simplified model of arterial bifurcations. 2009 Nov 1
61 18203325 High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis. 2008 Feb 3
62 18365690 Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. 2008 Feb 5
63 18635600 Role of MutS homolog 2 (MSH2) in intestinal myofibroblast proliferation during Crohn's disease stricture formation. 2008 Sep 1
64 18976673 Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation. 2008 Dec 5 1
65 16529752 Cerivastatin reduces cytokine-induced surface expression of ICAM-1 via increased shedding in human endothelial cells. 2007 Jan 1
66 16942919 Simvastatin stimulates macrophage interleukin-1beta secretion through an isoprenylation-dependent mechanism. 2007 Feb 2
67 17172275 Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells. 2007 Apr 2
68 17277159 Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. 2007 Feb 15 4
69 17377212 Simvastatin-induced prevention of the increase in TNF-alpha level in the acute phase of ischemic stroke. 2007 Jan-Feb 4
70 17464346 The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells. 2007 Feb 1
71 17519305 Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes. 2007 Aug 1
72 17560598 Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms. 2007 Aug 3
73 17716606 High dosage of simvastatin reduces TNF-alpha-induced apoptosis of endothelial progenitor cells but fails to prevent apoptosis induced by IL-1beta in vitro. 2007 Sep 3
74 17853009 Short-term effect of simvastatin treatment on inflammatory parameters in peritoneal dialysis patients. 2007 2
75 17901590 Inhibition of Barret's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins. 2007 Aug 1
76 18260853 [Clinico-diagnostic significance of cytokine activation and changes of morphofunctional parameters of the heart in patients with chronic heart failure and possibilities of correction of revealed disturbances with simvastatin]. 2007 1
77 16474306 [Effect of 6-month therapy with simvastatin on lipid transport function of the blood and the state of endothelium in patients with diabetes and hypertension]. 2006 1
78 16511915 Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. 2006 Mar 4
79 16518530 Early effects of simvastatin versus atorvastatin on oxidative stress and proinflammatory cytokines in hyperlipidemic subjects. 2006 Mar-Apr 1
80 16557230 Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. 2006 May 1
81 16740276 Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA. 2006 Sep 5 8
82 16870268 Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis. 2006 Sep 1
83 16978784 Suppressive effect of simvastatin on interferon-beta-induced expression of CC chemokine ligand 5 in microglia. 2006 Oct 30 2
84 17075836 RhoA-mediated, tumor necrosis factor alpha-induced activation of NF-kappaB in rheumatoid synoviocytes: inhibitory effect of simvastatin. 2006 Nov 2
85 17086617 Tumor necrosis factor-alpha as a potential target in the treatment of systemic lupus erythematosus: a role for the HMG-CoA reductase inhibitor simvastatin. 2006 Nov 1
86 15653378 Simvastatin decreases myocardial tumor necrosis factor alpha content in heart transplant recipients. 2005 Jan 6
87 15936988 Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. 2005 Sep 3
88 16265685 Effects of Angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with longterm rheumatoid arthritis. 2005 Nov 1
89 16465063 HMG-CoA reductase inhibitors reduce matrix metalloproteinase-9 activity in human varicose veins. 2005 Nov-Dec 1
90 15187114 Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors. 2004 Jun 15 3
91 15193818 Vascular effects of diet and statin in hypercholesterolemic patients. 2004 Jun 2
92 15210062 Effect of simvastatin on endothelium-dependent vaso-relaxation and endogenous nitric oxide synthase inhibitor. 2004 Jul 4
93 15221496 The effect of simvastatin on serum cytokine levels and bone metabolism in postmenopausal subjects: negative correlation between TNF-alpha and anabolic bone parameters. 2004 2
94 15234187 Simvastatin modulates TNFalpha-induced adhesion molecules expression in human endothelial cells. 2004 Jul 30 3
95 15458690 Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia. 2004 Nov 2
96 15520323 Simvastatin prevents vascular hyporeactivity during inflammation. 2004 Nov 23 1
97 15537504 Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin. 2004 Dec 1 3
98 15541048 Release of TNF-alpha from in vitro-stimulated monocytes is negatively associated with serum levels of apolipoprotein B in patients with type 2 diabetes. 2004 Nov 1
99 15786696 Simvastatin decreases concentration of interleukin-2 in hypercholesterolemic patients after treatment for 12 weeks. 2004 Jul-Dec 1
100 12472772 Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. 2003 Jan 3