Pub. Date : 2004 Dec 1
PMID : 15537504
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 2 | Simvastatin (0.1-10 mumol/l) concentration dependently inhibited TNFalpha-induced myofibroblast proliferation, invasion and MMP-9 secretion. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 3 | CONCLUSIONS: TNFalpha, acting predominantly via the TNF-R1 receptor, increased human atrial myofibroblast proliferation, invasion and MMP-9 secretion, all of which were inhibited by simvastatin. | Simvastatin | tumor necrosis factor | Homo sapiens |