Pub. Date : 2005 Jan
PMID : 15653378
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin decreases myocardial tumor necrosis factor alpha content in heart transplant recipients. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 2 | We studied the effects of simvastatin treatment on myocardial tumor necrosis factor alpha (TNF-alpha) expression; TNF-alpha is a potent pro-inflammatory cytokine associated with hypertrophy and fibrosis in heart transplant recipients. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 3 | We studied the effects of simvastatin treatment on myocardial tumor necrosis factor alpha (TNF-alpha) expression; TNF-alpha is a potent pro-inflammatory cytokine associated with hypertrophy and fibrosis in heart transplant recipients. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 4 | We studied the effects of simvastatin treatment on myocardial tumor necrosis factor alpha (TNF-alpha) expression; TNF-alpha is a potent pro-inflammatory cytokine associated with hypertrophy and fibrosis in heart transplant recipients. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 5 | At the 24(th) week after transplantation, when compared with Week 1 values, we found a significant decrease in myocardium TNF-alpha content in the simvastatin group (15.0% +/- 2.3% vs 5.8% +/- 2.4%, p = 0.02) that was not observed in the placebo group (15.0% +/- 1.5% vs 12.0% +/- 2.6%, p = not significant). | Simvastatin | tumor necrosis factor | Homo sapiens |
| 6 | CONCLUSION: Simvastatin treatment in heart transplant recipients decreased myocardium TNF-alpha expression. | Simvastatin | tumor necrosis factor | Homo sapiens |