Title : Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis.

Pub. Date : 2006 Sep

PMID : 16870268






1 Functional Relationships(s)
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1 Simvastatin inhibited IFN-gamma, TNF-alpha, and IL-2 secretion, as well as the expression of T-bet, a transcription factor that regulates Th1 cell differentiation. Simvastatin tumor necrosis factor Homo sapiens