Pub. Date : 2006 Sep 5
PMID : 16740276
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we demonstrate that the HMG-CoA reductase inhibitor simvastatin potentiates TNFalpha-mediated apoptosis and TNFalpha signaling in human umbilical vein endothelial cells (HUVECs). | Simvastatin | tumor necrosis factor | Homo sapiens |
| 2 | Here we demonstrate that the HMG-CoA reductase inhibitor simvastatin potentiates TNFalpha-mediated apoptosis and TNFalpha signaling in human umbilical vein endothelial cells (HUVECs). | Simvastatin | tumor necrosis factor | Homo sapiens |
| 3 | While 2.5 microM simvastatin or 40 ng/ml TNFalpha alone had only a small effect on apoptosis in HUVECs, co-incubation with simvastatin and TNFalpha markedly increased apoptosis in a time- and dose-dependent manner as measured by FACS analysis of propidium iodide-stained cells. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 4 | While 2.5 microM simvastatin or 40 ng/ml TNFalpha alone had only a small effect on apoptosis in HUVECs, co-incubation with simvastatin and TNFalpha markedly increased apoptosis in a time- and dose-dependent manner as measured by FACS analysis of propidium iodide-stained cells. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 5 | Furthermore, simvastatin increased the expression of the TNFalpha type I receptor (TNFalphaRI) with a dose dependence and a dependence on geranylgeranylation similar to that demonstrated for the potentiation of TNFalpha-mediated apoptosis. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 6 | Furthermore, simvastatin increased the expression of the TNFalpha type I receptor (TNFalphaRI) with a dose dependence and a dependence on geranylgeranylation similar to that demonstrated for the potentiation of TNFalpha-mediated apoptosis. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 7 | Simvastatin also potentiated TNFalpha signaling as determined by increased TNFalpha-mediated E-selectin expression. | Simvastatin | tumor necrosis factor | Homo sapiens |
| 8 | Simvastatin also potentiated TNFalpha signaling as determined by increased TNFalpha-mediated E-selectin expression. | Simvastatin | tumor necrosis factor | Homo sapiens |