Title : [Effects of metformin on the estrogen-induced proliferation and the expression of ER in human endometrial cancer cells].

Pub. Date : 2014 Dec

PMID : 25608995






2 Functional Relationships(s)
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1 By real-time FQ-PCR tested, the expression levels of c-fos and c-myc in both cell lines gradually declined subsequent to metformin treatment at different concentrations (1, 5 and 15 mmol/L). Metformin MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 As compared with the control group, the c-myc and c-fos expressions in both cell lines in metformin groups had significant differences (P < 0.05) except for the c-myc expression of the concentration of 1 mmol/L in HEC-1A cell line (P = 0.074). Metformin MYC proto-oncogene, bHLH transcription factor Homo sapiens