Title : Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells.

Pub. Date : 2020 Sep 25

PMID : 32728616






1 Functional Relationships(s)
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1 These findings demonstrate that c-Myc activates, whereas AMPK inhibits, TDG-mediated DNA demethylation of the SREBP1 promoter in insulin-promoted and metformin-suppressed cancer progression, respectively. Metformin MYC proto-oncogene, bHLH transcription factor Homo sapiens