Pub. Date : 2015
PMID : 26885449
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that metformin suppressed HSY cell growth in vitro in a time and dose dependent manner associated with a reduced expression of MYC onco-protein, and the same inhibitory effect of metformin was also confirmed in HSG cells. | Metformin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | In association with the reduction of MYC onco-protein, metformin significantly restored p53 tumor suppressor gene expression. | Metformin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | The distinctive effects of metformin and PP242 on MYC reduction and P53 restoration suggested that metformin inhibited cell growth through a different pathway from PP242 in salivary carcinoma cells. | Metformin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |