Title : Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway.

Pub. Date : 2012 Jun 8

PMID : 22575507






1 Functional Relationships(s)
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1 Finally, we found that metformin induced the degradation of the oncoproteins PML-RARalpha and c-Myc and activated caspase-3. Metformin MYC proto-oncogene, bHLH transcription factor Homo sapiens