Pub. Date : 1997 Sep 12
PMID : 9287333
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site. | Quinazolines | epidermal growth factor receptor | Homo sapiens |
| 2 | Submicromolar concentrations of AG-1478 and AG-1517, quinazolines specific for inhibition of the EGFR kinase, induced reversible receptor dimerization in vitro and in intact A431 cells. | Quinazolines | epidermal growth factor receptor | Homo sapiens |
| 3 | Quinazoline-induced EGFR dimerization was abrogated in vitro by ATP and the ATP analog adenyl-5"-yl imidodiphosphate. | Quinazolines | epidermal growth factor receptor | Homo sapiens |
| 4 | These data suggest that EGFR dimerization can be induced by the interaction of quinazolines at the ATP site in the absence of receptor ligand binding. | Quinazolines | epidermal growth factor receptor | Homo sapiens |
| 5 | In SKBR-3 cells, the quinazolines induced the formation of inactive EGFR/ErbB-2 heterodimers, potentially sequestering ErbB-2 from interacting with other coreceptors of the ErbB family. | Quinazolines | epidermal growth factor receptor | Homo sapiens |
| 6 | In SKBR-3 cells, the quinazolines induced the formation of inactive EGFR/ErbB-2 heterodimers, potentially sequestering ErbB-2 from interacting with other coreceptors of the ErbB family. | Quinazolines | epidermal growth factor receptor | Homo sapiens |
| 7 | Structural studies of the quinazoline interaction with the EGFR tyrosine kinase domain should allow for an analysis of receptor-specific chemical features required for binding to the ATP site and disruption of signaling, a strategy that can be perhaps applied to other tumor cell receptor systems. | Quinazolines | epidermal growth factor receptor | Homo sapiens |