| 1 |
30486276 | Galactosylated Chitosan-Functionalized Mesoporous Silica Nanoparticle Loading by Calcium Leucovorin for Colon Cancer Cell-Targeted Drug Delivery. | 2018 Nov 26 |
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| 2 |
21561529 | Calpain regulates thymidylate synthase-5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells. | 2011 Aug |
3 |
| 3 |
12684419 | Significance of thymidylate synthase activity in renal cell carcinoma. | 2003 Apr |
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| 4 |
12820419 | Induction of thymidine phosphorylase expression by Taxol does not enhance Furtulon sensitivity in a cisplatin-resistant human ovarian carcinoma cell line. | 2003 Mar-Apr |
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| 5 |
12883718 | Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: association with survival. | 2003 Sep-Oct |
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| 6 |
13680162 | Dihydropyrimidine dehydrogenase and thymidylate synthase activities in hepatocellular carcinomas and in diseased livers. | 2003 Dec |
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| 7 |
11836594 | Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer. | 2002 Mar-Apr |
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| 8 |
12084461 | Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. | 2002 Jul 18 |
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| 9 |
12167486 | Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase. | 2002 Aug 15 |
2 |
| 10 |
11212266 | Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase. | 2001 Jan 15 |
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| 11 |
10212232 | Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation. | 1999 Apr 30 |
2 |
| 12 |
10441376 | Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4. | 1999 Aug 15 |
2 |
| 13 |
10509749 | Genetic complementation and resistance to 5-fluoro-2'-deoxyuridine in thymidine auxotrophs expressing a highly defective mutant of human thymidylate synthase. | 1999 Sep 15 |
2 |
| 14 |
10535743 | Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line. | 1999 Nov 15 |
1 |
| 15 |
10652619 | Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. | 1999 Jul-Aug |
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| 16 |
10697629 | Thymidylate synthase levels as a therapeutic and prognostic predictor in breast cancer. | 1999 Nov-Dec |
2 |
| 17 |
9565579 | Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells. | 1998 May 8 |
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| 18 |
9155534 | Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells. | 1997 Mar |
2 |
| 19 |
9186496 | Functional effects of amino acid substitutions at residue 33 of human thymidylate synthase. | 1997 Jun 15 |
2 |
| 20 |
9535167 | Thymidylate synthase: structure, inhibition, and strained conformations during catalysis. | 1997 Oct-Dec |
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| 21 |
8632414 | Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase. | 1996 Feb 16 |
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| 22 |
8790719 | Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP. | 1996 |
2 |
| 23 |
8823494 | Effect of interferon on 5-fluorouracil-induced perturbations in pools of deoxynucleotide triphosphates and DNA strand breaks. | 1996 |
1 |
| 24 |
7641209 | The number of 5-fluoro-2'-deoxyuridine-5'-monophosphate binding sites and reduced folate pool in human colorectal carcinoma tissues: changes after tegafur and uracil treatment. | 1995 Sep 1 |
2 |
| 25 |
7763285 | Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. | 1995 May 17 |
1 |
| 26 |
8355668 | Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase. | 1993 Aug |
1 |
| 27 |
8461049 | Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase. | 1993 Mar 9 |
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| 28 |
1532344 | Enhancement of 5-fluoro-2'-deoxyuridine antineoplastic activity by 5-benzyloxybenzyloxybenzylacyclouridine in a human colon carcinoma cell line. | 1992 Apr 1 |
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| 29 |
1532673 | Mechanisms of resistance to fluoropyrimidines. | 1992 Apr |
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| 30 |
1557655 | Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. | 1992 Apr |
4 |
| 31 |
1596583 | Quantitation of dihydrofolate reductase and thymidylate synthase mRNAs in vivo and in vitro by polymerase chain reaction. | 1992 |
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| 32 |
1827310 | Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate. | 1991 |
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| 33 |
1924359 | Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. | 1991 Oct 15 |
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| 34 |
1992915 | [Drug concentration in cancerous large bowel tissue and thymidylate synthase inhibition rate after administration of tegafur and UFT]. | 1991 Feb |
2 |
| 35 |
1697502 | Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. | 1990 Sep 15 |
1 |
| 36 |
2142214 | Biochemical modulation of fluoropyrimidines by antifolates and folates in an in vitro model of human leukemia. | 1990 Feb |
2 |
| 37 |
2244925 | Thermodynamic study of the interaction of methotrexate, its metabolites, and new antifolates with thymidylate synthase: influence of FdUMP. | 1990 Nov 15 |
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| 38 |
2521810 | Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase. | 1989 Mar 15 |
2 |
| 39 |
2977717 | Tumor cell responses to inhibition of thymidylate synthase. | 1988 |
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| 40 |
3049954 | Fluorouracil: biochemistry and pharmacology. | 1988 Oct |
1 |
| 41 |
2963229 | Biochemical rationale for the synergism of 5-fluorouracil and folinic acid. | 1987 |
2 |
| 42 |
3126806 | Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase. | 1987 Dec 29 |
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| 43 |
3814166 | Studies on the interaction with thymidylate synthase of analogues of 2'-deoxyuridine-5'-phosphate and 5-fluoro-2'-deoxyuridine-5'-phosphate with modified phosphate groups. | 1987 Jan 15 |
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| 44 |
3745210 | Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates. | 1986 Sep 25 |
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| 45 |
6241433 | A method for the determination of total, free, and 5-fluorodeoxyuridylate-bound thymidylate synthase in cell extracts. | 1984 Nov 1 |
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| 46 |
139127 | A calorimetric study of the binding of 2'-deoxyuridine-5'-phosphate and 5-fluoro-2'-deoxyuridine-5'-phosphate to thymidylate synthetase. | 1977 Feb |
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