Title : Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.

Pub. Date : 1998 May 8

PMID : 9565579






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We postulate that the D49G or G52S mutation leads to the structural perturbation of the highly conserved Arg50 loop, decreasing the binding of thymidylate synthase to the inhibitors, Thymitaq and fluorodeoxyuridylate. Fluorodeoxyuridylate thymidylate synthetase Homo sapiens