Title : Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase.

Pub. Date : 2001 Jan 15

PMID : 11212266






1 Functional Relationships(s)
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Protein Name
Organism
1 In the cell, 5-FU is metabolized to 5-fluoro-2"-deoxyuridine 5"-monophosphate, a tight binding covalent inhibitor of thymidylate synthase. Fluorodeoxyuridylate thymidylate synthetase Homo sapiens