Title : Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation.

Pub. Date : 1999 Apr 30

PMID : 10212232






2 Functional Relationships(s)
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1 The fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine are cytotoxic as a consequence of inhibition of TS by the metabolite 5-fluoro-2"-deoxyuridine 5"-monophosphate (FdUMP). Fluorodeoxyuridylate thymidylate synthetase Homo sapiens
2 The fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine are cytotoxic as a consequence of inhibition of TS by the metabolite 5-fluoro-2"-deoxyuridine 5"-monophosphate (FdUMP). Fluorodeoxyuridylate thymidylate synthetase Homo sapiens