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29375377 | Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy. | 2017 |
1 |
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27006094 | A novel small molecule, Rosline, inhibits growth and induces caspase-dependent apoptosis in human lung cancer cells A549 through a reactive oxygen species-dependent mechanism. | 2016 Jun |
2 |
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27035545 | Diallyl trisulfide induces osteosarcoma cell apoptosis through reactive oxygen species-mediated downregulation of the PI3K/Akt pathway. | 2016 Jun |
2 |
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27106530 | Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells. | 2016 Jun 25 |
1 |
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27221553 | Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway. | 2016 Jul |
1 |
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27221774 | Flavonoid myricetin inhibits TNF-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-κB pathways in human keratinocytes. | 2016 Aug 5 |
1 |
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27590200 | Apocynin inhibits Toll-like receptor-4-mediated activation of NF-κB by suppressing the Akt and mTOR pathways. | 2016 Dec |
1 |
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27614430 | Bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells. | 2016 Dec |
1 |
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27687768 | Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways. | 2016 Sep 30 |
2 |
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27698876 | Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways. | 2016 Oct |
1 |
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27785026 | Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling. | 2016 |
1 |
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25338626 | Reactive oxygen species-mediated activation of the Src-epidermal growth factor receptor-Akt signaling cascade prevents bortezomib-induced apoptosis in hepatocellular carcinoma cells. | 2015 Jan |
1 |
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25444914 | Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells. | 2015 Feb 1 |
2 |
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25815442 | Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells. | 2015 Jul |
1 |
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25935150 | Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation. | 2015 May 3 |
2 |
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25971793 | Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-κB pathways. | 2015 Sep |
1 |
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26343756 | N-acetyl cysteine protects human oral keratinocytes from Bis-GMA-induced apoptosis and cell cycle arrest by inhibiting reactive oxygen species-mediated mitochondrial dysfunction and the PI3K/Akt pathway. | 2015 Dec |
2 |
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24355171 | Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets. | 2014 Mar |
2 |
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24378401 | Rotundarpene inhibits toll-like receptor 2 activation-induced production of inflammatory mediators in keratinocytes by suppressing the Akt and NF-κB pathways. | 2014 Feb |
1 |
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24700345 | Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression. | 2014 Jun |
2 |
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24769205 | High uric acid directly inhibits insulin signalling and induces insulin resistance. | 2014 May 16 |
1 |
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24907397 | Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells. | 2014 Aug |
1 |
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24919544 | Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species. | 2014 Jun 11 |
1 |
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22944050 | N-acetylcysteine (NAC) inhibits cell growth by mediating the EGFR/Akt/HMG box-containing protein 1 (HBP1) signaling pathway in invasive oral cancer. | 2013 Feb |
4 |
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23363008 | Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. | 2013 Feb 20 |
2 |
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23546866 | Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis. | 2013 Jul |
1 |
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23555559 | Critical role of H2O2 generated by NOX4 during cellular response under glucose deprivation. | 2013 |
2 |
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23623839 | Production of Cyr61 protein is modulated by extracellular acidification and PI3K/Akt signaling in prostate carcinoma PC-3 cells. | 2013 Aug |
1 |
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23640046 | Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. | 2013 Sep |
1 |
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24041743 | OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia through reactive oxygen species-mediated apoptosis. | 2013 Nov 15 |
1 |
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22622864 | Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. | 2012 Jun |
1 |
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22867088 | Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells. | 2012 Aug 6 |
1 |
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22878643 | The adenosine A3 receptor agonist Cl-IB-MECA induces cell death through Ca²⁺/ROS-dependent down regulation of ERK and Akt in A172 human glioma cells. | 2012 Dec |
1 |
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22946344 | Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent. | 2012 |
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23026832 | Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells. | 2012 Nov 15 |
1 |
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23156673 | N-acetylcysteine enhances neuronal differentiation of P19 embryonic stem cells via Akt and N-cadherin activation. | 2012 Sep-Oct |
2 |
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21055460 | Suppression of human prostate cancer PC-3 cell growth by N-acetylcysteine involves over-expression of Cyr61. | 2011 Feb |
1 |
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21620964 | An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-κB-independent mechanism. | 2011 Sep |
2 |
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21704193 | 3,4,5-Tricaffeoylquinic acid inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. | 2011 Nov |
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21728338 | Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells. | 2011 Aug 15 |
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23554696 | Activation of Rac1-PI3K/Akt is required for epidermal growth factor-induced PAK1 activation and cell migration in MDA-MB-231 breast cancer cells. | 2011 Jul |
1 |
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19782051 | Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism. | 2010 Feb 1 |
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19815813 | Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy. | 2010 Jan |
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19951696 | Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species. | 2010 Jan 1 |
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20112989 | Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. | 2010 Mar 15 |
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20570722 | Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles. | 2010 Aug 15 |
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19460788 | Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma. | 2009 Dec |
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19482076 | ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells. | 2009 Sep 1 |
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19737348 | Secreted phospholipase A2-IIA modulates key regulators of proliferation on astrocytoma cells. | 2009 Nov |
1 |
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19762915 | Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. | 2009 Nov 13 |
1 |