Title : Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis.

Pub. Date : 2013 Jul

PMID : 23546866






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Antioxidant N-acetyl cysteine attenuated ASK1 dephosphorylation and p38 MAPK activation, indicating that shikonin-induced ROS is involved in the activation of Akt/ASK1/p38 pathway. Acetylcysteine AKT serine/threonine kinase 1 Homo sapiens