Title : Activation of Rac1-PI3K/Akt is required for epidermal growth factor-induced PAK1 activation and cell migration in MDA-MB-231 breast cancer cells.

Pub. Date : 2011 Jul

PMID : 23554696






1 Functional Relationships(s)
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1 Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1. Acetylcysteine AKT serine/threonine kinase 1 Homo sapiens